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Haematopoietic stem cell self-renewal in vivo and ex vivo
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Abstract
The self-renewal capacity of multipotent haematopoietic stem cells (HSCs) supports
blood system homeostasis throughout life and underlies the curative capacity of clinical
HSC transplantation therapies. However, despite extensive characterization of the
HSC state in the adult bone marrow and embryonic fetal liver, the mechanism of HSC
self-renewal has remained elusive. This Review presents our current understanding
of HSC self-renewal in vivo and ex vivo, and discusses important advances in ex vivo
HSC expansion that are providing new biological insights and offering new therapeutic
opportunities.