Study of the viral interference between infectious pancreatic necrosis virus (IPNV) and infectious haematopoietic necrosis virus (IHNV) in rainbow trout (Oncorhynchus mykiss)
There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.
Abstract
The resistance of rainbow trout (Oncorhynchus mykiss) to an infectious haematopoietic
necrosis virus (IHNV) challenge following a preceding non-lethal infection with infectious
pancreatic necrosis virus (IPNV) was investigated through experimental dual infections.
Trout initially infected with IPNV were inoculated 14 days later with IHNV. Single
infections of trout with 1 of the 2 viruses or with cell culture supernatant were
also carried out and constituted control groups. No mortality was noted in fish after
a single infection with IPNV. This virus had no influence on the head kidney leucocyte
phagocytic activity and plasma haemolytic complement activity. IHNV induced a high
mortality (72%) and reduced the macrophage phagocytic activity and complement haemolytic
activity. It also induced a late production of anti-IHNV antibodies which occurred
after clearance of the virus in the fish. In trout co-infected with both viruses,
a mortality rate of 2% occurred and the immune parameters were similar to those observed
in the fish infected with IPNV only, demonstrating that in co-infected trout IPNV
inhibits the effects of IHNV. The studied parameters did not allow us to define the
mechanism of interference occurring between these 2 viruses, but some hypothesis are
put forward to explain the interference between the 2 viruses.