Haematopoietic stem cell self-renewal in vivo and ex vivo.

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Abstract

The self-renewal capacity of multipotent haematopoietic stem cells (HSCs) supports blood system homeostasis throughout life and underlies the curative capacity of clinical HSC transplantation therapies. However, despite extensive characterization of the HSC state in the adult bone marrow and embryonic fetal liver, the mechanism of HSC self-renewal has remained elusive. This Review presents our current understanding of HSC self-renewal in vivo and ex vivo, and discusses important advances in ex vivo HSC expansion that are providing new biological insights and offering new therapeutic opportunities.

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Journal

Journal ID (iso-abbrev): Nat Rev Genet

Title: Nature reviews. Genetics

Publisher: Springer Science and Business Media LLC

ISSN (Electronic): 1471-0064

ISSN (Print): 1471-0056

Publication date (Electronic): September 2020

Volume: 21

Issue: 9

Affiliations

[1 ] Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.

[2 ] Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.

[3 ] Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA. nakauchi@stanford.edu.

[4 ] Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA. nakauchi@stanford.edu.

[5 ] Division of Stem Cell Therapy, Distinguished Professor Unit, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan. nakauchi@stanford.edu.

Article

Publisher Item ID: 10.1038/s41576-020-0241-0 Mid ID: NIHMS1668264

DOI: 10.1038/s41576-020-0241-0

PMC ID: 7894993

PubMed ID: 32467607

SO-VID: e7b4d7a2-d960-4654-bee1-b17cde181866

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