Effectiveness of strontium/silver-based titanium surface coatings in improving antibacterial and osteogenic implant characteristics: a systematic review of <i>in-vitro</i> studies

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Abstract

Introduction: Due to the high incidence of implant failures, dual functionalization of titanium surfaces with antibacterial and osteogenic agents, like silver (Ag) and strontium (Sr), has gained significant attention in recent years. However, so far, the combined antibacterial and osteoinductive effectiveness of Ag/Sr-based titanium surface coatings has only been analyzed in individual studies.

Methods: This systematic review aims to evaluate the existing scientific literature regarding the PICOS question “Does dual incorporation of strontium/silver enhances the osteogenic and anti-bacterial characteristics of Ti surfaces in vitro?”. As a result of a web-based search adhering to the PRISMA Guidelines using three electronic databases (PubMed, Scopus, and Web of Science) until March 31, 2023, a total of 69 publications were identified as potentially relevant and 17 of which were considered appropriate for inclusion into this review.

Results and Discussion: In all included publications, the use of Sr/Ag combination showed enhanced osteogenic and antibacterial effects, either alone or in combination with other agents. Moreover, the combination of Sr and Ag shows potential to synergistically enhance these effects. Nevertheless, further studies need to validate these findings under clinically more relevant conditions and evaluate the mechanism of antimicrobial and osteogenic activity of Sr/Ag combination.

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PRISMA 2020 explanation and elaboration: updated guidance and exemplars for reporting systematic reviews

Matthew J Page (2021)

The methods and results of systematic reviews should be reported in sufficient detail to allow users to assess the trustworthiness and applicability of the review findings. The Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) statement was developed to facilitate transparent and complete reporting of systematic reviews and has been updated (to PRISMA 2020) to reflect recent advances in systematic review methodology and terminology. Here, we present the explanation and elaboration paper for PRISMA 2020, where we explain why reporting of each item is recommended, present bullet points that detail the reporting recommendations, and present examples from published reviews. We hope that changes to the content and structure of PRISMA 2020 will facilitate uptake of the guideline and lead to more transparent, complete, and accurate reporting of systematic reviews.

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Biofilms: an emergent form of bacterial life.

Hans-Curt Flemming, Jost Wingender, Ulrich Szewzyk … (2017)

Bacterial biofilms are formed by communities that are embedded in a self-produced matrix of extracellular polymeric substances (EPS). Importantly, bacteria in biofilms exhibit a set of 'emergent properties' that differ substantially from free-living bacterial cells. In this Review, we consider the fundamental role of the biofilm matrix in establishing the emergent properties of biofilms, describing how the characteristic features of biofilms - such as social cooperation, resource capture and enhanced survival of exposure to antimicrobials - all rely on the structural and functional properties of the matrix. Finally, we highlight the value of an ecological perspective in the study of the emergent properties of biofilms, which enables an appreciation of the ecological success of biofilms as habitat formers and, more generally, as a bacterial lifestyle.

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Bone grafts and biomaterials substitutes for bone defect repair: A review

Wenhao Wang, Kelvin W.K. Yeung (2017)

Bone grafts have been predominated used to treat bone defects, delayed union or non-union, and spinal fusion in orthopaedic clinically for a period of time, despite the emergency of synthetic bone graft substitutes. Nevertheless, the integration of allogeneic grafts and synthetic substitutes with host bone was found jeopardized in long-term follow-up studies. Hence, the enhancement of osteointegration of these grafts and substitutes with host bone is considerably important. To address this problem, addition of various growth factors, such as bone morphogenetic proteins (BMPs), parathyroid hormone (PTH) and platelet rich plasma (PRP), into structural allografts and synthetic substitutes have been considered. Although clinical applications of these factors have exhibited good bone formation, their further application was limited due to high cost and potential adverse side effects. Alternatively, bioinorganic ions such as magnesium, strontium and zinc are considered as alternative of osteogenic biological factors. Hence, this paper aims to review the currently available bone grafts and bone substitutes as well as the biological and bio-inorganic factors for the treatments of bone defect.

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Author and article information

Contributors

Marjan Kheirmand-Parizi: URI : https://loop.frontiersin.org/people/2583694/overviewRole: Role: Role:

Katharina Doll-Nikutta: URI : https://loop.frontiersin.org/people/2620904/overviewRole: Role: Role: Role:

Amit Gaikwad: URI : https://loop.frontiersin.org/people/1783210/overviewRole: Role:

Hannah Denis: URI : https://loop.frontiersin.org/people/2641097/overviewRole: Role: Role:

Meike Stiesch: Role: Role: Role:

Journal

Journal ID (nlm-ta): Front Bioeng Biotechnol

Journal ID (iso-abbrev): Front Bioeng Biotechnol

Journal ID (publisher-id): Front. Bioeng. Biotechnol.

Title: Frontiers in Bioengineering and Biotechnology

Publisher: Frontiers Media S.A.

ISSN (Electronic): 2296-4185

Publication date (Electronic): 29 February 2024

Publication date Collection: 2024

Volume: 12

Electronic Location Identifier: 1346426

Affiliations

[1] ¹ Department of Prosthetic Dentistry and Biomedical Materials Science , Hannover Medical School , Hannover, Germany

[2] ² Lower Saxony Center for Biomedical Engineering , Implant Research and Development (NIFE) , Hannover, Germany

Author notes

Edited by: Yori Endo, Brigham and Women’s Hospital and Harvard Medical School, United States

Reviewed by: Shokouh Attarilar, Shanghai Jiao Tong University, China

Agnese D’Agostino, Polytechnic University of Milan, Italy

*Correspondence: Marjan Kheirmand-Parizi, kheirmand-parizi.marjan@ 123456mh-hannover.de ; Meike Stiesch, stiesch.meike@ 123456mh-hannover.de

[ † ]

These authors have contributed equally to this work

Article

Publisher ID: 1346426

DOI: 10.3389/fbioe.2024.1346426

PMC ID: 10937591

PubMed ID: 38486866

SO-VID: a03e78b2-f5e7-413d-a839-66ce89f24ddd

License:

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

History

Date received : 30 November 2023

Date accepted : 16 February 2024

Funding

The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. This research was Funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)–SFB/TRR-298-SIIRI–Project-ID 426335750. The authors thank Dr. Andreas Winkel for supporting with the biorender-created scheme.

Custom metadata

section-at-acceptance Biomaterials

Keywords: antibacterial,osteogenic,silver,strontium,titanium

Data availability:

Keywords: antibacterial, osteogenic, silver, strontium, titanium

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