Ezh2 lines up the chromatin in T regulatory cells.

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

Epigenetic modulation is critical for regulating the development and function of T cells. In this issue of Immunity, DuPage et al. (2015) show that the chromatin-modifying enzyme Ezh2 induced by CD28 costimulation is essential for regulatory T (Treg) cell maintenance during activation and differentiation.

Related collections

Author and article information

Journal

Journal ID (iso-abbrev): Immunity

Title: Immunity

ISSN (Electronic): 1097-4180

ISSN (Print): 1074-7613

Publication date (Electronic): Feb 17 2015

Volume: 42

Issue: 2

Affiliations

[1 ] Evergrande Center for Immunologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, MA 02115, USA.

[2 ] Evergrande Center for Immunologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, MA 02115, USA. Electronic address: vkuchroo@evergrande.hms.harvard.edu.

Article

Publisher Item ID: S1074-7613(15)00045-X

DOI: 10.1016/j.immuni.2015.01.019

PubMed ID: 25692693

SO-VID: 2c212482-86f3-43c8-ac18-56d0216280dd

History

Data availability:

Comments

Comment on this article

scite_

Cited by 6

See all cited by

- Version 1