Roots of Astragalus propinquus Schischkin Regulate Transmembrane Iron Transport and Ferroptosis to Improve Cerebral Ischemia-Reperfusion Injury.

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Abstract

The dried roots of the Astragalus propinquus Schischkin (RAP) plant, as a traditional Chinese medicine, has been widely used to treat stroke, cerebral ischemia, qi deficiency, and hypertension. Buyang Huanwu decoction is traditionally used to treat stroke in China for more than 200 years and has a significant effect on cerebral ischemia, and RAP is monarch medicine of Buyang Huanwu decoction. Therefore, this study was designed to observe the regulatory effect of RAP on transmembrane iron transporters and ferroptosis-related factors in cerebral ischemia-reperfusion injury (CIRI) in rats.

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Journal

Journal ID (iso-abbrev): Evid Based Complement Alternat Med

Title: Evidence-based complementary and alternative medicine : eCAM

Publisher: Hindawi Limited

ISSN: 1741-427X

ISSN (Print): 1741-427X

Publication date (Electronic): 2022

Volume: 2022

Affiliations

[1 ] Graduate School, Hebei University of Chinese Medicine, Shijiazhuang 050200, Hebei, China.

[2 ] College of Pharmacy, Hebei University of Chinese Medicine, Shijiazhuang 050200, Hebei, China.

[3 ] Hebei Key Laboratory of Chinese Medicine Research on Cardio-Cerebrovascular Disease, Shijiazhuang 050200, China.

[4 ] College of Basic Medicine, Hebei University of Chinese Medicine, Shijiazhuang 050200, Hebei, China.

Article

DOI: 10.1155/2022/7410865

PMC ID: 9363172

PubMed ID: 35958925

SO-VID: fe977736-cc27-43f0-af51-f1eec6a63b5d

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