We study a possible origin of single spin asymmetries in the large pT inclusive production of hadrons in the scattering of unpolarized protons or leptons on transversely polarized nucleons. Such asymmetry is related to the single-spin asymmetry for the process \p↑→q+X or, equivalently, to the off-diagonal matrix element of the quark density operator ˉψγ+ψ; this quantity need not be zero if transverse momentum and spin-isospin interactions are taken into account. The different signs for the large single spin asymmetries observed in \p↑p→π+X and \p↑p→π−X can be explained as a consequence of chiral symmetry. Crucial tests of the model are suggested.