GERMINAL CENTER B CELL DYNAMICS

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Abstract

Germinal centers (GCs) are the site of antibody diversification and affinity maturation, and as such are vitally important for humoral immunity. The study of GC biology has undergone a renaissance in the past 10 years, with a succession of findings that have transformed our understanding of the cellular dynamics of affinity maturation. In this review, we discuss recent developments in the field, with special emphasis on how GC cellular and clonal dynamics shape antibody affinity and diversity during the immune response.

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Journal

Journal ID (nlm-journal-id): 9432918

Journal ID (pubmed-jr-id): 8591

Journal ID (nlm-ta): Immunity

Journal ID (iso-abbrev): Immunity

Title: Immunity

ISSN (Print): 1074-7613

ISSN (Electronic): 1097-4180

Publication date Nihms-submitted: 1 October 2016

Publication date (Print): 20 September 2016

Publication date PMC-release: 20 September 2017

Volume: 45

Issue: 3

Pages: 471-482

Affiliations

Whitehead Institute for Biomedical Research, Cambridge, MA, 02142, USA

Author notes

Address correspondence to: victora@ 123456wi.mit.edu

Article

Accession ID: PMC5123673 Pmcid ID: PMC5123673 Pmc-uid ID: 5123673 Manuscript ID: nihpa820000

DOI: 10.1016/j.immuni.2016.09.001

PMC ID: 5123673

PubMed ID: 27653600

SO-VID: e8c5fda7-216c-4bbb-b44c-1be87076e07a

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