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      Free radical scavenging properties of mannitol and its role as a constituent of hyaluronic acid fillers: a literature review.

      1 , 2
      International journal of cosmetic science
      Wiley
      aesthetic, antioxidant, free radical, hyaluronic acid, mannitol

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          Abstract

          Mannitol has both hydrating and antioxidant properties that make it an ideal excipient for use with hyaluronic acid (HA) fillers. This review examines the role of reactive oxygen species in the ageing process and their effects on both endogenous HA and HA products developed for aesthetic use. Evidence is presented to show that the free radical scavenging properties of mannitol provide it with a two-fold mechanism of action when combined with HA fillers: reducing the inflammation and swelling associated with the injection procedure itself, and preventing the degradation of the injected HA by free radicals. Mannitol also has a long- and well-established safety profile in both the food and pharmaceutical industry. Having established the rationale for using mannitol in combination with an HA filler, the products using this strategy are then reviewed. The addition of mannitol to HA fillers is a viable and safe option for improving both short- and long-term HA aesthetic effects.

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          Author and article information

          Journal
          Int J Cosmet Sci
          International journal of cosmetic science
          Wiley
          1468-2494
          0142-5463
          Aug 2017
          : 39
          : 4
          Affiliations
          [1 ] Paris-Université Laser Skin Clinic, 157, rue de l'Université, 75007, Paris, France.
          [2 ] Merz Pharmaceuticals GmbH, 100 Eckenheimer Landstrasse, 60318, Frankfurt am Main, Germany.
          Article
          10.1111/ics.12386
          28027572
          d45e8c92-6d91-4f34-9f5e-933ee829e704
          © 2016 Society of Cosmetic Scientists and the Société Française de Cosmétologie.
          History

          aesthetic,antioxidant,free radical,hyaluronic acid,mannitol
          aesthetic, antioxidant, free radical, hyaluronic acid, mannitol

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