Formylpeptide receptor single nucleotide polymorphism 348T>C and its relationship to polymorphonuclear leukocyte chemotaxis in aggressive periodontitis.

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Abstract

Aggressive periodontitis (AgP) is associated with impaired polymorphonuclear leukocyte (PMN) chemotaxis toward bacterial N-formylpeptides. Formylpeptide receptors (FPRs) play a major role in guiding PMNs to infection sites. Previous work revealed a significant association between FPR1 single nucleotide polymorphism (SNP) 348T>C and AgP in African Americans. We tested the hypothesis that 348T impairs PMN chemotaxis by decreasing FPR mRNA expression, thereby increasing susceptibility to AgP.

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Journal

Journal ID (iso-abbrev): J. Periodontol.

Title: Journal of periodontology

Publisher: American Academy of Periodontology (AAP)

ISSN: 0022-3492

ISSN (Print): 0022-3492

Publication date (Electronic): Sep 2009

Volume: 80

Issue: 9

Affiliations

[1 ] Division of Periodontology, College of Dentistry, The Ohio State University, Health Sciences Center, Columbus, OH 43210, USA.

Article

Mid ID: NIHMS114112

DOI: 10.1902/jop.2009.090103

PMC ID: 2739129

PubMed ID: 19722801

SO-VID: d36c8a7e-c77d-4ae6-b35e-1a1a3e482afd

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