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Enantiopure isoindolinones through Viedma ripening.
René R E Steendam
1 ,
Maxime C T Brouwer ,
Evelien M E Huijs ,
Michaël W Kulka ,
Hugo Meekes ,
Willem J P van Enckevort ,
Jan Raap ,
Floris P J T Rutjes ,
Elias Vlieg
Oct 13 2014
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Abstract
Here we demonstrate that deracemization of isoindolinones using Viedma ripening is possible starting from a racemic mixture of conglomerate crystals. Crystals of the enantiopure isoindolinones lose their chiral identity upon dissolution even without the need for a catalyst. This enabled complete deracemization of the reported isoindolinones without a catalyst.