Pharmacological and therapeutic potential of Cordyceps with special reference to Cordycepin

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Abstract

An entomopathogenic fungus, Cordyceps sp. has been known to have numerous pharmacological and therapeutic implications, especially, in terms of human health making it a suitable candidate for ethno-pharmacological use. Main constituent of the extract derived from this fungus comprises a novel bio-metabolite called as Cordycepin (3′deoxyadenosine) which has a very potent anti-cancer, anti-oxidant and anti-inflammatory activities. The current review discusses about the broad spectrum potential of Cordycepin including biological and pharmacological actions in immunological, hepatic, renal, cardiovascular systems as well as an anti-cancer agent. The article also reviews the current efforts to delineate the mechanism of action of Cordycepin in various bio-molecular processes. The study will certainly draw the attention of scientific community to improve the bioactivity and production of Cordycepin for its commercial use in pharmacological and medical fields.

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Most cited references 142

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Interactions Between Fungal Pathogens and Insect Hosts

A E Hajek, R St Leger (1994)

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Cordyceps – A traditional Chinese medicine and another fungal therapeutic biofactory?

R. Paterson (2008)

Graphical abstract (a) The Yin and Yang symbol: The philosophical basis of some of the assumed properties and research on Cordyceps (see text)? (b) Cordyceps spp. parasitizing a dead Campanotus insect and (c) cordyheptapeptide A, a natural product from the fungus.

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Medicinal uses of the mushroom Cordyceps militaris: current state and prospects.

Shonkor Kumar Das, Mina Masuda, Akihiko Sakurai … (2010)

Cordyceps militaris is a potential harbour of bio-metabolites for herbal drugs and evidences are available about its applications for revitalization of various systems of the body from ancient times. Amongst all the species, C. militaris is considered as the oldest source of some useful chemical constituents. Besides their popular applications for tonic medicine by the all stairs of the community, the constituents of C. militaris are now used extensively in modern systems of medicine. The current survey records the mysterious potentials of C. militaris are boosting up the present herbal treatments, as well as gearing up the green pharmacy revolution, in order to create a friendly environment with reasonable safety. Evidence showed that the active principles of C. militaris are beneficial to act as pro-sexual, anti-inflammatory, anti-oxidant/anti-aging, anti-tumour/anti-cancer/anti-leukemic, anti-proliferative, anti-metastatic, immunomodulatory, anti-microbial, anti-bacterial, anti-viral, anti-fungal, anti-protozoal, insecticidal, larvicidal, anti-fibrotic, steroidogenic, hypoglacaemic, hypolipidaemic, anti-angiogenetic, anti-diabetic, anti-HIV, anti-malarial, anti-fatigue, neuroprotective, liver-protective, reno-protective as well as pneumo-protective, let alone their other synergistic activities, which let it be marketable in the western countries as over-the-counter medicine. A number of culture techniques for this mushroom have been noticed, for example, storage/stock culture, pre-culture, popular/indigenous culture (spawn culture, husked rice culture and saw dust culture) and, special/laboratory culture (shaking culture, submerged culture, surface liquid culture and continuous/repeated batch culture). The prospects for herbal biotechnology regarding drug discovery using C. militaris delivering what it has promised are high, as the technology is now extremely more powerful than before. This study chiefly highlights the medicinal uses of the mushroom C. militaris including its culture techniques, also aiming to draw sufficient attention of the researchers to the frontier research needs in this context. Copyright © 2010 Elsevier B.V. All rights reserved.

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Author and article information

Contributors

: +91-8059777758 , +91-01731274375 , anibiotech18@gmail.com

Journal

Journal ID (nlm-ta): 3 Biotech

Journal ID (iso-abbrev): 3 Biotech

Title: 3 Biotech

Publisher: Springer Berlin Heidelberg (Berlin/Heidelberg )

ISSN (Print): 2190-572X

ISSN (Electronic): 2190-5738

Publication date (Electronic): 19 February 2013

Publication date PMC-release: 19 February 2013

Publication date (Print): February 2014

Volume: 4

Issue: 1

Pages: 1-12

Affiliations

[ ]Department of Biotechnology, M.M.E.C., Maharishi Markandeshwar University, Mullana, Ambala, 133203 Haryana India

[ ]Department of Biological Sciences, R. D. University, Jabalpur, 482001 MP India

Article

Publisher ID: 121

DOI: 10.1007/s13205-013-0121-9

PMC ID: 3909570

PubMed ID: 28324458

SO-VID: c126129e-4c38-49c0-948a-b59ef060aa46

License:

Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.

History

Date received : 1 October 2012

Date accepted : 2 February 2013

Custom metadata

Keywords: infection,cordycepin,pharmacological effect,cordyceps militaris,mechanism

Data availability:

Keywords: infection, cordycepin, pharmacological effect, cordyceps militaris, mechanism

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