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      Melanoma skin cancer detection using mask-RCNN with modified GRU model

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          Abstract

          Introduction: Melanoma Skin Cancer (MSC) is a type of cancer in the human body; therefore, early disease diagnosis is essential for reducing the mortality rate. However, dermoscopic image analysis poses challenges due to factors such as color illumination, light reflections, and the varying sizes and shapes of lesions. To overcome these challenges, an automated framework is proposed in this manuscript.

          Methods: Initially, dermoscopic images are acquired from two online benchmark datasets: International Skin Imaging Collaboration (ISIC) 2020 and Human against Machine (HAM) 10000. Subsequently, a normalization technique is employed on the dermoscopic images to decrease noise impact, outliers, and variations in the pixels. Furthermore, cancerous regions in the pre-processed images are segmented utilizing the mask-faster Region based Convolutional Neural Network (RCNN) model. The mask-RCNN model offers precise pixellevel segmentation by accurately delineating object boundaries. From the partitioned cancerous regions, discriminative feature vectors are extracted by applying three pre-trained CNN models, namely ResNeXt101, Xception, and InceptionV3. These feature vectors are passed into the modified Gated Recurrent Unit (GRU) model for MSC classification. In the modified GRU model, a swish-Rectified Linear Unit (ReLU) activation function is incorporated that efficiently stabilizes the learning process with better convergence rate during training.

          Results and discussion: The empirical investigation demonstrate that the modified GRU model attained an accuracy of 99.95% and 99.98% on the ISIC 2020 and HAM 10000 datasets, where the obtained results surpass the conventional detection models.

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          Most cited references45

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          The HAM10000 dataset, a large collection of multi-source dermatoscopic images of common pigmented skin lesions

          Training of neural networks for automated diagnosis of pigmented skin lesions is hampered by the small size and lack of diversity of available datasets of dermatoscopic images. We tackle this problem by releasing the HAM10000 (“Human Against Machine with 10000 training images”) dataset. We collected dermatoscopic images from different populations acquired and stored by different modalities. Given this diversity we had to apply different acquisition and cleaning methods and developed semi-automatic workflows utilizing specifically trained neural networks. The final dataset consists of 10015 dermatoscopic images which are released as a training set for academic machine learning purposes and are publicly available through the ISIC archive. This benchmark dataset can be used for machine learning and for comparisons with human experts. Cases include a representative collection of all important diagnostic categories in the realm of pigmented lesions. More than 50% of lesions have been confirmed by pathology, while the ground truth for the rest of the cases was either follow-up, expert consensus, or confirmation by in-vivo confocal microscopy.
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            A patient-centric dataset of images and metadata for identifying melanomas using clinical context

            Prior skin image datasets have not addressed patient-level information obtained from multiple skin lesions from the same patient. Though artificial intelligence classification algorithms have achieved expert-level performance in controlled studies examining single images, in practice dermatologists base their judgment holistically from multiple lesions on the same patient. The 2020 SIIM-ISIC Melanoma Classification challenge dataset described herein was constructed to address this discrepancy between prior challenges and clinical practice, providing for each image in the dataset an identifier allowing lesions from the same patient to be mapped to one another. This patient-level contextual information is frequently used by clinicians to diagnose melanoma and is especially useful in ruling out false positives in patients with many atypical nevi. The dataset represents 2,056 patients (20.8% with at least one melanoma, 79.2% with zero melanomas) from three continents with an average of 16 lesions per patient, consisting of 33,126 dermoscopic images and 584 (1.8%) histopathologically confirmed melanomas compared with benign melanoma mimickers.
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              Skin Lesion Segmentation and Multiclass Classification Using Deep Learning Features and Improved Moth Flame Optimization

              Manual diagnosis of skin cancer is time-consuming and expensive; therefore, it is essential to develop automated diagnostics methods with the ability to classify multiclass skin lesions with greater accuracy. We propose a fully automated approach for multiclass skin lesion segmentation and classification by using the most discriminant deep features. First, the input images are initially enhanced using local color-controlled histogram intensity values (LCcHIV). Next, saliency is estimated using a novel Deep Saliency Segmentation method, which uses a custom convolutional neural network (CNN) of ten layers. The generated heat map is converted into a binary image using a thresholding function. Next, the segmented color lesion images are used for feature extraction by a deep pre-trained CNN model. To avoid the curse of dimensionality, we implement an improved moth flame optimization (IMFO) algorithm to select the most discriminant features. The resultant features are fused using a multiset maximum correlation analysis (MMCA) and classified using the Kernel Extreme Learning Machine (KELM) classifier. The segmentation performance of the proposed methodology is analyzed on ISBI 2016, ISBI 2017, ISIC 2018, and PH2 datasets, achieving an accuracy of 95.38%, 95.79%, 92.69%, and 98.70%, respectively. The classification performance is evaluated on the HAM10000 dataset and achieved an accuracy of 90.67%. To prove the effectiveness of the proposed methods, we present a comparison with the state-of-the-art techniques.
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                Author and article information

                Contributors
                URI : https://loop.frontiersin.org/people/2560561/overviewRole: Role:
                Role: Role:
                URI : https://loop.frontiersin.org/people/2271549/overviewRole: Role:
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                Journal
                Front Physiol
                Front Physiol
                Front. Physiol.
                Frontiers in Physiology
                Frontiers Media S.A.
                1664-042X
                16 January 2024
                2023
                : 14
                : 1324042
                Affiliations
                [1] 1 School of Computer Science and Engineering , Vellore Institute of Technology , Chennai, Tamil Nadu, India
                [2] 2 Department of Computer Science and Engineering , Rao Bahadur Y. Mahabaleswarappa Engineering College , Ballari, Karnataka, India
                [3] 3 Faculty of Electronics, Telecommunications and Informatics , Gdansk of Technology , Gdansk, Poland
                [4] 4 Specialist Diabetes Outpatient Clinic , Olsztyn, Poland
                [5] 5 Department of Engineering and Technology , Bharati Vidyapeeth Peeth Deemed to be University , Navi Mumbai, Maharashtra, India
                [6] 6 Department of Electronics and Communication Engineering , Nitte Meenakshi Institute of Technology , Bangalore, Karnataka, India
                Author notes

                Edited by: Domenico L. Gatti, Wayne State University, United States

                Reviewed by: Luigi Leonardo Palese, University of Bari Aldo Moro, Italy

                Ma Khan, HITEC University, Pakistan

                *Correspondence: Przemysław Falkowski-Gilski, przemyslaw.falkowski@ 123456eti.pg.edu.pl
                Article
                1324042
                10.3389/fphys.2023.1324042
                10825805
                38292449
                9c7bb451-222c-4cdd-a6bc-73082a14595d
                Copyright © 2024 Monica, Shreeharsha, Falkowski-Gilski, Falkowska-Gilska, Awasthy and Phadke.

                This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

                History
                : 24 October 2023
                : 18 December 2023
                Funding
                The author(s) declare that no financial support was received for the research, authorship, and/or publication of this article.
                Categories
                Physiology
                Original Research
                Custom metadata
                Computational Physiology and Medicine

                Anatomy & Physiology
                faster region based convolutional neural network,gated recurrent unit,melanoma skin cancer detection,normalization,pre-trained models

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