Tildrakizumab versus placebo or etanercept for chronic plaque psoriasis (reSURFACE 1 and reSURFACE 2): results from two randomised controlled, phase 3 trials.

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

Tildrakizumab is a high-affinity, humanised, IgG1 κ antibody targeting interleukin 23 p19 that represents an evolving treatment strategy in chronic plaque psoriasis. Previous research suggested clinical improvement with inhibition of interleukin 23 p19. We did two phase 3 trials to investigate whether tildrakizumab is superior to placebo and etanercept in the treatment of chronic plaque psoriasis.

Related collections

Author and article information

Journal

Journal ID (iso-abbrev): Lancet

Title: Lancet (London, England)

Publisher: Elsevier BV

ISSN (Electronic): 1474-547X

ISSN (Print): 0140-6736

Publication date (Electronic): July 15 2017

Volume: 390

Issue: 10091

Affiliations

[1 ] SCIderm Research Institute and Dermatologikum Hamburg, Hamburg, Germany. Electronic address: kreich@dermatologikum.de.

[2 ] Probity Medical Research, Waterloo, ON, Canada.

[3 ] Oregon Medical Research Center, Portland, OR, USA.

[4 ] Department of Dermatology, University of Texas Health Science Center, Houston, TX, USA.

[5 ] Epworth Hospital Department of Dermatology, University of Melbourne, Melbourne, VIC, Australia.

[6 ] Comprehensive Center for Inflammation Medicine, University Medical School Schleswig-Holstein, University of Lübeck, Lübeck, Germany.

[7 ] Merck & Co, Kenilworth, NJ, USA.

[8 ] Harvard Medical School, Boston, MA, USA.

Article

Publisher Item ID: S0140-6736(17)31279-5

DOI: 10.1016/S0140-6736(17)31279-5

PubMed ID: 28596043

SO-VID: 9a859fe3-a739-4d30-b022-149826920566

History

Data availability:

Comments

Comment on this article

scite_

Smart Citations

Citing PublicationsSupportingMentioningContrasting

View Citations

See how this article has been cited at scite.ai

scite shows how a scientific paper has been cited by providing the context of the citation, a classification describing whether it supports, mentions, or contrasts the cited claim, and a label indicating in which section the citation was made.