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      Recent advances in skin-like wearable sensors: sensor design, health monitoring, and intelligent auxiliary

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          Abstract

          Recent advances in health monitoring devices and intelligent assistive devices based on skin sensors.

          Abstract

          When entering old age, the tissue structure of the body begins to age, the functions of various organs appear disordered, resistance declines and is prone to various geriatric diseases. Geriatric diseases are characterized by a long course of the disease, slow recovery, and high medical costs. Therefore, a simple, rapid, economical, and effective method is urgently needed to detect the indicators of patients for long-term and continuous monitoring to reduce the medical burden. Wearable sensors, with their advantages of real-time, economical, simple operation, and non-invasion have attracted extensive attention and have good application potential in the health monitoring of elderly patients and the development of intelligent auxiliary devices. This paper reviews the research progress of skin-like wearable sensors in health monitoring and intelligent auxiliary devices in recent years. According to different sensing mechanisms, this paper introduces skin-like wearable sensors for health monitoring, including electrochemistry, bioimpedance, photoelectricity, and other wearable sensors, as well as related research for the development of intelligent auxiliary devices. Finally, this paper summarizes the applications and future challenges of developing the skin-like wearable sensor into a widely used and accepted home medical device for elderly patients.

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          Most cited references157

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          Fully integrated wearable sensor arrays for multiplexed in situ perspiration analysis.

          Wearable sensor technologies are essential to the realization of personalized medicine through continuously monitoring an individual's state of health. Sampling human sweat, which is rich in physiological information, could enable non-invasive monitoring. Previously reported sweat-based and other non-invasive biosensors either can only monitor a single analyte at a time or lack on-site signal processing circuitry and sensor calibration mechanisms for accurate analysis of the physiological state. Given the complexity of sweat secretion, simultaneous and multiplexed screening of target biomarkers is critical and requires full system integration to ensure the accuracy of measurements. Here we present a mechanically flexible and fully integrated (that is, no external analysis is needed) sensor array for multiplexed in situ perspiration analysis, which simultaneously and selectively measures sweat metabolites (such as glucose and lactate) and electrolytes (such as sodium and potassium ions), as well as the skin temperature (to calibrate the response of the sensors). Our work bridges the technological gap between signal transduction, conditioning (amplification and filtering), processing and wireless transmission in wearable biosensors by merging plastic-based sensors that interface with the skin with silicon integrated circuits consolidated on a flexible circuit board for complex signal processing. This application could not have been realized using either of these technologies alone owing to their respective inherent limitations. The wearable system is used to measure the detailed sweat profile of human subjects engaged in prolonged indoor and outdoor physical activities, and to make a real-time assessment of the physiological state of the subjects. This platform enables a wide range of personalized diagnostic and physiological monitoring applications.
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            Stretchable, Skin-Mountable, and Wearable Strain Sensors and Their Potential Applications: A Review

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              Epidermal electronics.

              We report classes of electronic systems that achieve thicknesses, effective elastic moduli, bending stiffnesses, and areal mass densities matched to the epidermis. Unlike traditional wafer-based technologies, laminating such devices onto the skin leads to conformal contact and adequate adhesion based on van der Waals interactions alone, in a manner that is mechanically invisible to the user. We describe systems incorporating electrophysiological, temperature, and strain sensors, as well as transistors, light-emitting diodes, photodetectors, radio frequency inductors, capacitors, oscillators, and rectifying diodes. Solar cells and wireless coils provide options for power supply. We used this type of technology to measure electrical activity produced by the heart, brain, and skeletal muscles and show that the resulting data contain sufficient information for an unusual type of computer game controller.
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                Author and article information

                Contributors
                (View ORCID Profile)
                (View ORCID Profile)
                Journal
                SDEIAR
                Sensors & Diagnostics
                Sens. Diagn.
                Royal Society of Chemistry (RSC)
                2635-0998
                July 14 2022
                2022
                : 1
                : 4
                : 686-708
                Affiliations
                [1 ]Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Wuhan University of Science and Technology, Wuhan 430065, PR China
                [2 ]School of Public Health, Medical College, Wuhan University of Science and Technology, Wuhan 430065, PR China
                [3 ]Central War Zone General Hospital, Hankou Hospital District, 68 Huangpu Street, Jiang'an District, Wuhan, 430070, PR China
                [4 ]Institute for Schistosomiasis Control, 104 Jinguang Street, Huang'pi District, Wuhan, 430399, PR China
                [5 ]Institute of Analytical Sciences, UMR-CNRS 5280, University of Lyon, 5, La Doua Street, Villeurbanne 69100, France
                Article
                10.1039/D2SD00037G
                8f8c79a2-91aa-4dd5-8840-24a32ad608eb
                © 2022

                http://creativecommons.org/licenses/by-nc/3.0/

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