Recent advances in the material design for intelligent wearable devices

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Abstract

A flexible sensor is a key part of intelligent wearable devices. The design of micro–nano structured materials in sensors is crucial. Therefore, the recent application of micro–nano structured materials in intelligent wearable devices is summarized.

Abstract

With the rapid development of intelligent devices, medical devices, flexible robots, and other fields, it is an inevitable trend of future development for intelligent wearable devices to replace traditional bulky electronic devices. The design of traditional macroscopic electronic devices can no longer satisfy the requirements of intelligent wearable devices. To realize the efficient application of intelligent wearable devices, the design of micro–nano structured materials in electronic devices is crucial for accurate real-time acquisition of signals from human physiological movements and environmental changes. This article reviews the recent application of micro–nano structured materials in intelligent wearable devices, including material composition design, structure design, and the applications of intelligent wearable device. Finally, the challenges and opportunities of novel materials in the application of intelligent wearable devices are discussed.

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Is Open Access

U1 snRNP regulates cancer cell migration and invasion in vitro

Jung-Min Oh, Christopher Venters, Chao Di … (2020)

Stimulated cells and cancer cells have widespread shortening of mRNA 3’-untranslated regions (3’UTRs) and switches to shorter mRNA isoforms due to usage of more proximal polyadenylation signals (PASs) in introns and last exons. U1 snRNP (U1), vertebrates’ most abundant non-coding (spliceosomal) small nuclear RNA, silences proximal PASs and its inhibition with antisense morpholino oligonucleotides (U1 AMO) triggers widespread premature transcription termination and mRNA shortening. Here we show that low U1 AMO doses increase cancer cells’ migration and invasion in vitro by up to 500%, whereas U1 over-expression has the opposite effect. In addition to 3’UTR length, numerous transcriptome changes that could contribute to this phenotype are observed, including alternative splicing, and mRNA expression levels of proto-oncogenes and tumor suppressors. These findings reveal an unexpected role for U1 homeostasis (available U1 relative to transcription) in oncogenic and activated cell states, and suggest U1 as a potential target for their modulation.