- Record: found
- Abstract: not found
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Highly Enantio- and Diastereoselective Generation of Two Quaternary Centers in Spirocyclopropanation of Oxindole Derivatives.
Artur Noole ,
Natalia S. Sucman ,
Mikhail A. Kabeshov ,
Tõnis Kanger ,
Fliur Z. Macaev ,
Andrei V. Malkov
November 19 2012
November 19 2012
There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.
Abstract
Spirocyclopropanes: Only one out of eight possible stereoisomers was obtained in the
asymmetric cascade cyclopropanation of alkylidene oxindoles with ethyl 2-chloroacetoacetate.
Improved catalyst design ensured that spirocyclopropyl oxindoles featuring two quaternary
centers were synthesized in high yield and high enantio- and diastereoselectivity
(see scheme).
Related collections
Most cited references29
- Record: found
- Abstract: not found
- Article: not found
Targeting Structural and Stereochemical Complexity by Organocascade Catalysis: Construction of Spirocyclic Oxindoles Having Multiple Stereocenters
Li-Yuan Wu, Giorgio Bencivenni, Andrea Mazzanti … (2009)
- Record: found
- Abstract: not found
- Article: not found
Urea- and Thiourea-Substituted Cinchona Alkaloid Derivatives as Highly Efficient Bifunctional Organocatalysts for the Asymmetric Addition of Malonate to Nitroalkenes: Inversion of Configuration at C9 Dramatically Improves Catalyst Performance.
Séamus H. McCooey, Stephen J Connon (2005)
- Record: found
- Abstract: not found
- Article: not found
Cinchona Alkaloids in Asymmetric Organocatalysis
Tommaso Marcelli, Henk Hiemstra (2010)