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The red blood cell proportion of arachidonic acid relates to shorter leukocyte telomeres in Mediterranean elders: A secondary analysis of a randomized controlled trial
Tania-Marisa Freitas-Simoes ,
Montserrat Cofán ,
Maria A. Blasco ,
Nora Soberón ,
Miguel Foronda ,
Dolores Corella ,
Eva M. Asensio ,
Mercè Serra-Mir ,
Irene Roth ,
Carlos Calvo ,
Cinta Valls-Pedret ,
Ricardo P. Casaroli-Marano ,
Mónica Doménech ,
Sujatha Rajaram ,
Joan Sabaté ,
Emilio Ros ,
Aleix Sala-Vila
February 2018
February 2018
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Abstract
Shortening of leukocyte telomere length (LTL) is a biomarker of aging. Epidemiologic
studies of LTL in relation to dietary fatty acids have reported conflicting results.
The red blood cell (RBC) fatty acid status is a valid objective biomarker of long-term
dietary intake of C18:2n-6, C18:3n-3 and long-chain n-3 polyunsaturated fatty acids
(C20:5n-3 and C22:6n-3). In healthy older individuals, we investigated whether LTL
relates to the RBC proportions of the main dietary polyunsaturated fatty acids (PUFA),
and to the RBC proportion of arachidonic acid (C20:4n-6), a fatty acid that can generate
pro-inflammatory lipid mediators once released from cell membranes.