The red blood cell proportion of arachidonic acid relates to shorter leukocyte telomeres in Mediterranean elders: A secondary analysis of a randomized controlled trial.

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Abstract

Shortening of leukocyte telomere length (LTL) is a biomarker of aging. Epidemiologic studies of LTL in relation to dietary fatty acids have reported conflicting results. The red blood cell (RBC) fatty acid status is a valid objective biomarker of long-term dietary intake of C18:2n-6, C18:3n-3 and long-chain n-3 polyunsaturated fatty acids (C20:5n-3 and C22:6n-3). In healthy older individuals, we investigated whether LTL relates to the RBC proportions of the main dietary polyunsaturated fatty acids (PUFA), and to the RBC proportion of arachidonic acid (C20:4n-6), a fatty acid that can generate pro-inflammatory lipid mediators once released from cell membranes.

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Journal

Journal ID (iso-abbrev): Clin Nutr

Title: Clinical nutrition (Edinburgh, Scotland)

Publisher: Elsevier BV

ISSN (Electronic): 1532-1983

ISSN (Print): 0261-5614

Publication date (Electronic): April 2019

Volume: 38

Issue: 2

Affiliations

[1 ] Lipid Clinic, Department of Endocrinology and Nutrition, Hospital Clínic de Barcelona, Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona, Spain.

[2 ] Lipid Clinic, Department of Endocrinology and Nutrition, Hospital Clínic de Barcelona, Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona, Spain; Ciber Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.

[3 ] Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.

[4 ] Ciber Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain; Department of Preventive Medicine, University of Valencia, Valencia, Spain.

[5 ] Department of Surgery, School of Medicine, University of Barcelona, Barcelona, Spain.

[6 ] Department of Nutrition, School of Public Health, Loma Linda University, Loma Linda, CA, USA.

[7 ] Lipid Clinic, Department of Endocrinology and Nutrition, Hospital Clínic de Barcelona, Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona, Spain; Ciber Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. Electronic address: asala@clinic.ub.es.

Article

Publisher Item ID: S0261-5614(18)30074-8

DOI: 10.1016/j.clnu.2018.02.011

PubMed ID: 29478886

SO-VID: 743078aa-251f-47d5-be71-f48bf4518f51

History

Keywords: Telomeres,Aging,Fatty acids,PUFA

Data availability:

Keywords: Telomeres, Aging, Fatty acids, PUFA

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