Research review: Polygenic methods and their application to psychiatric traits.

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Abstract

Despite evidence from twin and family studies for an important contribution of genetic factors to both childhood and adult onset psychiatric disorders, identifying robustly associated specific DNA variants has proved challenging. In the pregenomics era the genetic architecture (number, frequency and effect size of risk variants) of complex genetic disorders was unknown. Empirical evidence for the genetic architecture of psychiatric disorders is emerging from the genetic studies of the last 5 years.

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Author and article information

Journal

Journal ID (iso-abbrev): J Child Psychol Psychiatry

Title: Journal of child psychology and psychiatry, and allied disciplines

Publisher: Wiley

ISSN (Electronic): 1469-7610

ISSN (Print): 0021-9630

Publication date (Electronic): Oct 2014

Volume: 55

Issue: 10

Affiliations

[1 ] Queensland Brain Institute, The University of Queensland, St Lucia, Qld, Australia.

Article

DOI: 10.1111/jcpp.12295

PubMed ID: 25132410

SO-VID: 725ca4cd-fdb2-416a-a613-27cf83bc8852

History

Keywords: Polygenic risk scoring,SNP analyses,disease traits,genome-wide association studies,heritability,psychiatric disorders

Data availability:

Keywords: Polygenic risk scoring, SNP analyses, disease traits, genome-wide association studies, heritability, psychiatric disorders

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