Ribo-gnome: the big world of small RNAs.

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Abstract

Small RNA guides--microRNAs, small interfering RNAs, and repeat-associated small interfering RNAs, 21 to 30 nucleotides in length--shape diverse cellular pathways, from chromosome architecture to stem cell maintenance. Fifteen years after the discovery of RNA silencing, we are only just beginning to understand the depth and complexity of how these RNAs regulate gene expression and to consider their role in shaping the evolutionary history of higher eukaryotes.

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Journal

Journal ID (iso-abbrev): Science

Title: Science (New York, N.Y.)

Publisher: American Association for the Advancement of Science (AAAS)

ISSN (Electronic): 1095-9203

ISSN (Print): 0036-8075

Publication date (Electronic): Sep 02 2005

Volume: 309

Issue: 5740

Affiliations

[1 ] Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA. phillip.zamore@umassmed.edu

Article

Publisher Item ID: 309/5740/1519

DOI: 10.1126/science.1111444

PubMed ID: 16141061

SO-VID: 65de2d70-8ee4-48da-bd68-4532b51e513f

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