17
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Differences between asthmatics and nonasthmatics hospitalised with influenza A infection

      research-article

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Asthmatics hospitalised because of influenza A infection are less likely to require intensive care or die compared with nonasthmatics. The reasons for this are unknown.

          We performed a retrospective analysis of data on 1520 patients admitted to 75 UK hospitals with confirmed influenza A/H1N1 2009 infection. A multivariable model was used to investigate reasons for the association between asthma and severe outcomes (intensive care unit support or death).

          Asthmatics were less likely than nonasthmatics to have severe outcome (11.2% versus 19.8%, unadjusted OR 0.51, 95% CI 0.36–0.72) despite a greater proportion requiring oxygen on admission (36.4% versus 26%, unadjusted OR 1.63) and similar rates of pneumonia (17.1% versus 16.6%, unadjusted OR 1.04). The results of multivariable logistic regression suggest the association of asthma with outcome (adjusted OR 0.62, 95% CI 0.36–1.05; p=0.075) are explained by pre-admission inhaled corticosteroid use (adjusted OR 0.34, 95% CI 0.18–0.66) and earlier admission (≤4 days from symptom onset) (adjusted OR 0.60, 95% CI 0.38–0.94). In asthmatics, systemic corticosteroids were associated with a decreased likelihood of severe outcomes (adjusted OR 0.36, 95% CI 0.18–0.72).

          Corticosteroid use and earlier hospital admission explained the association of asthma with less severe outcomes in hospitalised patients.

          Related collections

          Author and article information

          Journal
          Eur Respir J
          Eur. Respir. J
          erj
          The European Respiratory Journal
          European Respiratory Society (442 Glossop Road, Sheffield, S10 2PX, UK )
          0903-1936
          1399-3003
          April 2013
          16 August 2012
          : 41
          : 4
          : 824-831
          Affiliations
          [* ]Division of Epidemiology and Public Health, University of Nottingham , Nottingham
          [# ]Dept of Women’s and Children’s Health, Institute of Translational Medicine, University of Liverpool , Liverpool
          []Centre for Peri-operative Medicine and Critical Care Research, Imperial College Healthcare NHS Trust , London
          [+ ]Dept of Health , London
          [§ ]Infectious Diseases, University of Southampton , Southampton
          [f ]Dept of Infection and Immunity, University of Sheffield , Royal Hallamshire Hospital, Sheffield
          [** ]Dept of Critical Care, Portsmouth Hospitals NHS Trust , Portsmouth
          [## ]Health Protection Scotland , NHS National Services, Glasgow
          [¶¶ ]Infectious Diseases Unit, University Hospitals of Leicester NHS Trust , Leicester Royal Infirmary, Leicester
          [§§ ]Centre for Respiratory Infections, National Heart and Lung Institute, Imperial College , London
          [++ ]Nottingham University Hospitals NHS Trust , Dept of Respiratory Medicine, Nottingham, UK
          Author notes
          W.S. Lim, Dept of Respiratory Medicine, Nottingham University, Hospitals NHS Trust, David Evans Building, Hucknall Road, Nottingham NG5 1PB, UK, E-mail: weishen.lim@ 123456nuh.nhs.uk
          Article
          erj00155-2012
          10.1183/09031936.00015512
          3612580
          22903963
          54fdef22-d0d7-407d-8992-93b383c051e6
          ©ERS 2013

          ERJ Open articles are open access and distributed under the terms of the ( Creative Commons Attribution Licence 3.0> )

          History
          : 25 January 2012
          : 25 June 2012
          Categories
          Original Article
          Asthma
          2
          4

          Respiratory medicine
          asthma,corticosteroids,influenza,inhaled corticosteroid therapy,mortality in asthma,prognosis

          Comments

          Comment on this article