Cancer of the gastroesophageal junction: a diagnosis, classification, and management review

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Abstract

Management of gastroesophageal junction (GEJ) adenocarcinoma is a controversial topic. The rising incidence of this cancer requires a clear consensus to ensure proper management. Application of oncological principles for tumors of the esophagus or stomach is not possible because of comparative differences in the biology of GEJ adenocarcinoma, leading to different therapeutic options. Staging work-up with endoscopy, endosonography, and PET is essential to inform the choice of neoadjuvant treatment and surgical approach to GEJ adenocarcinoma. Surgery remains the only curative treatment and should be undertaken in specialized centers.

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Author and article information

Journal

Title: Annals of the New York Academy of Sciences

Abbreviated Title: Ann. N.Y. Acad. Sci.

Publisher: Wiley

ISSN (Print): 0077-8923

ISSN (Electronic): 1749-6632

Publication date Created: July 05 2018

Publication date Created: December 2018

Publication date (Electronic): August 23 2018

Publication date (Print): December 2018

Volume: 1434

Issue: 1

Pages: 132-138

Affiliations

[1 ]Visceral Surgery DepartmentGeneva University Hospital Genève Switzerland

[2 ]Department of Visceral and Vascular SurgeryUniversity of Cologne Cologne Germany

[3 ]Department of Surgical Gastroenterology and Center of Excellence for Upper Gastro Intestinal SurgeryMadras Medical College and Rajiv Gandhi Government General Hospital Chennai India

[4 ]Department of General, Visceral and Transplantation SurgeryUniversity Hospital Heidelberg Heidelberg Germany

[5 ]Department of SurgeryParacelsus Medical University Salzburg Austria

[6 ]Department of General SurgeryUniversity of Verona Verona Italy

[7 ]Department of SurgeryRoyal Marsden Hospital London UK