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      High prevalence of macrolide resistance in Mycoplasma pneumoniae isolates from adult and adolescent patients with respiratory tract infection in China.

      Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
      Adolescent, Adult, Anti-Bacterial Agents, pharmacology, therapeutic use, Child, China, DNA, Bacterial, chemistry, genetics, Drug Resistance, Bacterial, Female, Genes, rRNA, Humans, Macrolides, Male, Middle Aged, Molecular Sequence Data, Mycoplasma pneumoniae, drug effects, isolation & purification, Pneumonia, Mycoplasma, microbiology, Point Mutation, RNA, Ribosomal, 23S, Sequence Analysis, DNA, Treatment Outcome, Young Adult

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          Abstract

          The resistance rate of 67 Mycoplasma pneumoniae isolates from 356 ambulatory adult patients with respiratory tract infection was 69% (46 of 67). All 46 macrolide-resistant strains harbored point mutations in the 23S ribosomal RNA gene. Patients infected with macrolide-resistant M. pneumoniae required significantly longer durations of antibiotic therapy and had longer time to resolution of fever.

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