Antibacterial properties of magnesium in vitro and in an in vivo model of implant-associated methicillin-resistant Staphylococcus aureus infection.

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Abstract

Periprosthetic infection remains a challenging clinical complication. We investigated the antibacterial properties of pure (99.9%) magnesium (Mg) in vitro and in an in vivo rat model of implant-related infection. Mg was highly effective against methicillin-resistant Staphylococcus aureus-induced osteomyelitis and improved new peri-implant bone formation. Bacterial icaA and agr RNAIII transcription levels were also assessed to characterize the mechanism underlying the antibacterial properties of the Mg implant.

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Journal

Journal ID (iso-abbrev): Antimicrob. Agents Chemother.

Title: Antimicrobial agents and chemotherapy

Publisher: American Society for Microbiology

ISSN (Electronic): 1098-6596

ISSN (Print): 0066-4804

Publication date (Electronic): Dec 2014

Volume: 58

Issue: 12

Affiliations

[1 ] Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

[2 ] Department of Orthopaedic Surgery, the Central Hospital of Xuzhou, Xuzhou Clinical School of Xuzhou Medical College, Xuzhou Hospital (affiliated with Medical College of Southeast University), Jiangsu, China.

[3 ] Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

[4 ] Institute of Metal Research, Chinese Academy of Sciences, Shenyang, China.

[5 ] Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China xinhua_qu@126.com krdai@163.com.

Article

Publisher Item ID: AAC.03936-14

DOI: 10.1128/AAC.03936-14

PMC ID: 4249557

PubMed ID: 25288077

SO-VID: 3370a0a1-eddf-4091-929e-42123635b205

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