Alterations in fibrillin as well as collagens I and III and elastin occur in vulval lichen sclerosus.

Abstract

The clinical features of lichen sclerosus, which include atrophy, scarring, fragility and tendency to form ecchymoses with only slight trauma, suggest that there is an alteration in the extracellular matrix fibres that are responsible for the tensile strength of the dermis. However, the precise nature of these changes is poorly understood.