Therapeutic Potential of Quercetin: New Insights and
Perspectives for Human Health

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Abstract

Quercetin (Que) and its derivatives are naturally occurring phytochemicals with promising bioactive effects. The antidiabetic, anti-inflammatory, antioxidant, antimicrobial, anti-Alzheimer’s, antiarthritic, cardiovascular, and wound-healing effects of Que have been extensively investigated, as well as its anticancer activity against different cancer cell lines has been recently reported. Que and its derivatives are found predominantly in the Western diet, and people might benefit from their protective effect just by taking them via diets or as a food supplement. Bioavailability-related drug-delivery systems of Que have also been markedly exploited, and Que nanoparticles appear as a promising platform to enhance their bioavailability. The present review aims to provide a brief overview of the therapeutic effects, new insights, and upcoming perspectives of Que.

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Burden of liver diseases in the world

Sumeet K Asrani, Harshad Devarbhavi, John Eaton … (2019)

Liver disease accounts for approximately 2 million deaths per year worldwide, 1 million due to complications of cirrhosis and 1million due to viral hepatitis and hepatocellular carcinoma. Cirrhosis is currently the 11th most common cause of death globally and liver cancer is the 16th leading cause of death; combined, they account for 3.5% of all deaths worldwide. Cirrhosis is within the top 20 causes of disability-adjusted life years and years of life lost, accounting for 1.6% and 2.1% of the worldwide burden. About 2 billion people consume alcohol worldwide and upwards of 75 million are diagnosed with alcohol-use disorders and are at risk of alcohol-associated liver disease. Approximately 2 billion adults are obese or overweight and over 400 million have diabetes; both of which are risk factors for non-alcoholic fatty liver disease and hepatocellular carcinoma. The global prevalence of viral hepatitis remains high, while drug-induced liver injury continues to increase as a major cause of acute hepatitis. Liver transplantation is the second most common solid organ transplantation, yet less than 10% of global transplantation needs are met at current rates. Though these numbers are sobering, they highlight an important opportunity to improve public health given that most causes of liver diseases are preventable.

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Lead- and drug-like compounds: the rule-of-five revolution.

Christopher A. Lipinski (2004)

Citations in CAS SciFinder to the rule-of-five (RO5) publication will exceed 1000 by year-end 2004. Trends in the RO5 literature explosion that can be discerned are the further definitions of drug-like. This topic is explored in terms of drug-like physicochemical features, drug-like structural features, a comparison of drug-like and non-drug-like in drug discovery and a discussion of how drug-like features relate to clinical success. Physicochemical features of CNS drugs and features related to CNS blood-brain transporter affinity are briefly reviewed. Recent literature on features of non-oral drugs is reviewed and how features of lead-like compounds differ from those of drug-like compounds is discussed. Most recently, partly driven by NIH roadmap initiatives, considerations have arisen as to what tool-like means in the search for chemical tools to probe biology space. All these topics frame the scope of this short review/perspective.: © 2004 Elsevier Ltd . All rights reserved.

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Overviews of Biological Importance of Quercetin: A Bioactive Flavonoid

Alexander Anand David, Radhakrishnan Arulmoli, Subramani Parasuraman (2016)

Antioxidants are substances that may protect cells from the damage caused by unstable molecules such as free radicals. Flavonoids are phenolic substances widely found in fruits and vegetables. The previous studies showed that the ingestion of flavonoids reduces the risk of cardiovascular diseases, metabolic disorders, and certain types of cancer. These effects are due to the physiological activity of flavonoids in the reduction of oxidative stress, inhibiting low-density lipoproteins oxidation and platelet aggregation, and acting as vasodilators in blood vessels. Free radicals are constantly generated resulting in extensive damage to tissues leading to various disease conditions such as cancer, Alzheimer's, renal diseases, cardiac abnormalities, etc., Medicinal plants with antioxidant properties play a vital functions in exhibiting beneficial effects and employed as an alternative source of medicine to mitigate the disease associated with oxidative stress. Flavonoids have existed over one billion years and possess wide spectrum of biological activities that might be able to influence processes which are dysregulated in a disease. Quercetin, a plant pigment is a potent antioxidant flavonoid and more specifically a flavonol, found mostly in onions, grapes, berries, cherries, broccoli, and citrus fruits. It is a versatile antioxidant known to possess protective abilities against tissue injury induced by various drug toxicities.

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Author and article information

Journal

Journal ID (nlm-ta): ACS Omega

Journal ID (iso-abbrev): ACS Omega

Journal ID (publisher-id): ao

Journal ID (coden): acsodf

Title: ACS Omega

Publisher: American Chemical Society

ISSN (Electronic): 2470-1343

Publication date (Electronic): 14 May 2020

Publication date Collection: 26 May 2020

Volume: 5

Issue: 20

Pages: 11849-11872

Affiliations

[† ]Student Research Committee, School of Medicine, Bam University of Medical Sciences , Bam 44340847, Iran

[‡ ]Institute of Pharmacy and Food, University of Havana , Havana, Cuba

[§ ]Parasitology Department, Institute of Medicine Tropical Pedro Kourí , Havana, Cuba

[∥ ]Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences , Tehran 1991953381, Iran

[⊥ ]Department of Pharmacognosy, Faculty of Pharmacy, Cairo University , Kasr El-Aini Street, Cairo 11562, Egypt

[# ]Department of Pharmacognosy, Faculty of Pharmacy, October University for Modern Sciences and Arts (MSA) , 6th October 12566, Egypt

[∇ ]Department of Pharmacognosy, Faculty of Pharmacy, Menoufia University , Gamal Abd El Nasr st., Shibin Elkom, Menoufia 32511, Egypt

[○ ]Department of Pharmacognosy, National Research Centre , Giza 12622, Egypt

[◆ ]Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, October University for Modern Sciences and Arts (MSA) , 6th of October 12566, Egypt

[¶ ]Department of Pharmaceutical Botany, Faculty of Pharmacy, Ankara University , Ankara 06100, Turkey

[†† ]Department of Plant Biology Department, Institute of Biology, Taras Shevchenko National University of Kyiv , Volodymyrska str., 64, Kyiv 01033, Ukraine

[‡‡ ]Department of Plant Physiology, Slovak University of Agriculture , Nitra, A. Hlinku 2, Nitra 94976, Slovak Republic

[§§ ]Department of Medical Parasitology, Faculty of Medicine, Kerman University of Medical Sciences , Kerman 7616913555, Iran

[∥∥ ]Department of Pharmaceutical Technology, Avicenna Tajik State Medical University , Rudaki 139, Dushanbe 734003, Tajikistan

[⊥⊥ ]Faculty of Medicine, University of Porto , Porto 4200-319, Portugal

[## ]Institute for Research and Innovation in Health (i3S), University of Porto , Porto 4200-135, Portugal

[∇∇ ]Department of Nutrition and Dietetics, Faculty of Pharmacy, and Centre for Healthy Living, University of Concepción , Concepción 4070386, Chile

[○○ ]Universidad de Concepción, Unidad de Desarrollo Tecnológico, UDT , Concepción 4070386, Chile

[◆◆ ]Department of Clinical Oncology, Queen Elizabeth Hospital , 30 Gascoigne Road, Kowloon, Hong Kong

Author notes

[* ]Email: javad.sharifirad@ 123456gmail.com .

[* ]Email: shahira.ezzat@ 123456pharma.cu.edu.eg .

[* ]Email: ncmartins@ 123456med.up.pt .

[* ]Email: mmartorell@ 123456udec.cl .

[* ]Email: chocs@ 123456ha.org.hk .

Article

DOI: 10.1021/acsomega.0c01818

PMC ID: 7254783

PubMed ID: 32478277

SO-VID: 11877a6b-0b5c-4e90-93d9-8e1e51f99250

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This is an open access article published under a Creative Commons Attribution (CC-BY) License, which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.

History

Date received : 20 April 2020

Date accepted : 01 May 2020

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Therapeutic Potential of Quercetin: New Insights and Perspectives for Human Health

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Most cited references 292

Burden of liver diseases in the world

Lead- and drug-like compounds: the rule-of-five revolution.

Overviews of Biological Importance of Quercetin: A Bioactive Flavonoid

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Cited by 135

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