For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
Inviting an author to review:
Embarazo en la adolescencia y los indicadores de salud materna y perinatal <span class="so-article-trans-title" dir="auto"> Translated title: Adolescent pregnancy and maternal and perinatal health indicators </span>
Find an author and click ‘Invite to review selected article’ near their name.
Search for authorsSearch for similar articles
15
views
Article has an altmetric score of 5
32
references
 Top references
cited by
2
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      702
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      CYFRA 21-1 in urine: a diagnostic marker for endometriosis?

      Read this article at

      ScienceOpenPublisherPMC
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Diagnostic workup of endometriosis usually involves laparoscopic inspection and histological examination of biopsies. Unequivocal laboratory parameters for this ailment have not been available in routine diagnostic evaluations thus far. In this study, we examined urine concentrations of cytokeratin 19 (CYFRA 21-1), a structural protein specific for epithelia. We performed immunoassays for CYFRA 21-1 in urine samples from women afflicted with endometriosis throughout their menstrual cycle. We observed a significant increase in CYFRA 21-1 concentrations, corrected by creatinine levels, in the late follicular phase as compared with the level in healthy controls. We conclude that cyclically increased CYFRA 21-1 concentrations in urine could serve as a valuable noninvasive diagnostic parameter in the workup of clinically manifesting endometriosis.

          Related collections

          Most cited references32

          • Record: found
          • Abstract: found
          • Article: not found

          Incidence of laparoscopically confirmed endometriosis by demographic, anthropometric, and lifestyle factors.

          Stacey Missmer, Susan E Hankinson, Donna Spiegelman … (2004)
          The authors investigated the relations of demographic, anthropometric, and lifestyle factors with endometriosis in the Nurses' Health Study II prospective cohort. During 10 years of follow-up (1989-1999), 1,721 cases of laparoscopically confirmed endometriosis were reported among women with no past infertility. The incidence rate was greatest among women aged 25-29 years and lowest among women over 44 years (p(trend) 30 vs. 19-20.4 kg/m(2): rate ratio = 0.8, 95% confidence interval: 0.6, 1.1; p(trend) = 0.004) and with current alcohol intake (for >10 vs. 0 g/day: rate ratio = 0.7, 95% confidence interval: 0.6, 0.8; p(trend) < 0.0001) but no association with height, waist/hip ratio, or caffeine intake. An inverse relation with current body mass index and current cigarette smoking was observed only when cases were concurrently infertile. The authors conclude that age, race, body mass index, alcohol use, and cigarette smoking are associated with the incidence of endometriosis and that some of these relations may differ by infertility status at the time of laparoscopic diagnosis.
          Article 0 comments Cited 151 times – based on 0 reviews     Review now
          Article has an altmetric score of 9
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            What's the delay? A qualitative study of women's experiences of reaching a diagnosis of endometriosis.

            Jeremy Wright, K Ballard, Karen Lowton (2006)
            To investigate the reasons women experience delays in the diagnosis of endometriosis and the impact of this. A qualitative interview-based study of 32 women, 28 of whom were subsequently diagnosed with endometriosis. Southeast England. Women attending a pelvic pain clinic. Semistructured interviews. Women's reported experiences of being diagnosed with endometriosis. Delays in the diagnosis of endometriosis occur at an individual patient level and a medical level, as both women and family doctors normalize symptoms, symptoms are suppressed through hormones, and nondiscriminatory investigations are relied upon. Women benefited from a diagnosis, because it provided a language in which to discuss their condition, offered possible management strategies to control symptoms, and provided reassurance that symptoms were not due to cancer. Diagnosis also sanctioned women's access to social support and legitimized absences from social and work obligations. Although recent guidelines for the management of chronic pelvic pain suggest that diagnostic laparoscopy may be considered a secondary investigation after the failure of therapeutic interventions, the present study highlights the importance of an early diagnosis for women who suffer at physical, emotional, and social levels when they remain undiagnosed.
            Article 0 comments Cited 148 times – based on 0 reviews     Review now
            Article has an altmetric score of 163
              Bookmark
              • Record: found
              • Abstract: not found
              • Article: not found

              Practice bulletin no. 114: management of endometriosis.

              (2010)
              Article 0 comments Cited 92 times – based on 0 reviews     Review now
              Article has an altmetric score of 220
                Bookmark
                All references

                Author and article information

                Journal
                Journal ID (iso-abbrev): Int J Womens Health
                Title: International journal of women's health
                Publisher: Informa UK Limited
                ISSN: 1179-1411
                ISSN (Print): 1179-1411
                Publication date (Electronic): 2015
                Volume: 7
                Affiliations
                [1 ] Department of Laboratory Medicine, Bodenseelabor, Hörbranz, Austria ; Institute of Anatomy II, University of Jena, Jena University Hospital, Jena, Germany.
                Article
                Publisher Item ID: ijwh-7-205
                DOI: 10.2147/IJWH.S75288
                PMC ID: 4332289
                PubMed ID: 25709504
                SO-VID: 1c85246e-2b16-4303-9862-81256c85f17a
                History

                Keywords: CYFRA 21-1,biomarkers,immunoassay,menstrual cycle,noninvasive diagnosis
                Data availability:
                Keywords: CYFRA 21-1, biomarkers, immunoassay, menstrual cycle, noninvasive diagnosis

                Comments

                Comment on this article

                scite_
                0
                0
                0
                0
                Smart Citations
                0
                0
                0
                0
                Citing PublicationsSupportingMentioningContrasting
                View Citations

                See how this article has been cited at scite.ai

                scite shows how a scientific paper has been cited by providing the context of the citation, a classification describing whether it supports, mentions, or contrasts the cited claim, and a label indicating in which section the citation was made.

                Similar content702

                See all similar

                Cited by2

                See all cited by

                Most referenced authors329

                See all reference authors