New insights on the cardiovascular effects of IGF-1

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Abstract

Introduction

Cardiovascular (CV) disorders are steadily increasing, making them the world’s most prevalent health issue. New research highlights the importance of insulin-like growth factor 1 (IGF-1) for maintaining CV health

Methods

We searched PubMed and MEDLINE for English and non-English articles with English abstracts published between 1957 (when the first report on IGF-1 identification was published) and 2022. The top search terms were: IGF-1, cardiovascular disease, IGF-1 receptors, IGF-1 and microRNAs, therapeutic interventions with IGF-1, IGF-1 and diabetes, IGF-1 and cardiovascular disease. The search retrieved original peer-reviewed articles, which were further analyzed, focusing on the role of IGF-1 in pathophysiological conditions. We specifically focused on including the most recent findings published in the past five years.

Results

IGF-1, an anabolic growth factor, regulates cell division, proliferation, and survival. In addition to its well-known growth-promoting and metabolic effects, there is mounting evidence that IGF-1 plays a specialized role in the complex activities that underpin CV function. IGF-1 promotes cardiac development and improves cardiac output, stroke volume, contractility, and ejection fraction. Furthermore, IGF-1 mediates many growth hormones (GH) actions. IGF-1 stimulates contractility and tissue remodeling in humans to improve heart function after myocardial infarction. IGF-1 also improves the lipid profile, lowers insulin levels, increases insulin sensitivity, and promotes glucose metabolism. These findings point to the intriguing medicinal potential of IGF-1. Human studies associate low serum levels of free or total IGF-1 with an increased risk of CV and cerebrovascular illness. Extensive human trials are being conducted to investigate the therapeutic efficacy and outcomes of IGF-1-related therapy.

Discussion

We anticipate the development of novel IGF-1-related therapy with minimal side effects. This review discusses recent findings on the role of IGF-1 in the cardiovascular (CVD) system, including both normal and pathological conditions. We also discuss progress in therapeutic interventions aimed at targeting the IGF axis and provide insights into the epigenetic regulation of IGF-1 mediated by microRNAs.

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Most cited references 228

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Author and article information

Contributors

Mirjana Macvanin: URI : https://loop.frontiersin.org/people/174475

Zoran Gluvic: URI : https://loop.frontiersin.org/people/953422

Jelena Radovanovic: URI : https://loop.frontiersin.org/people/981639

Magbubah Essack: URI : https://loop.frontiersin.org/people/183085

Xin Gao: URI : https://loop.frontiersin.org/people/329785

Esma R. Isenovic: URI : https://loop.frontiersin.org/people/887392

Journal

Journal ID (nlm-ta): Front Endocrinol (Lausanne)

Journal ID (iso-abbrev): Front Endocrinol (Lausanne)

Journal ID (publisher-id): Front. Endocrinol.

Title: Frontiers in Endocrinology

Publisher: Frontiers Media S.A.

ISSN (Electronic): 1664-2392

Publication date (Electronic): 09 February 2023

Publication date Collection: 2023

Volume: 14

Electronic Location Identifier: 1142644

Affiliations

[1] ¹ Department of Radiobiology and Molecular Genetics, VINČA Institute of Nuclear Sciences - National Institute of the Republic of Serbia, University of Belgrade , Belgrade, Serbia

[2] ² Clinic for Internal Medicine, Department of Endocrinology and Diabetes, Zemun Clinical Hospital, School of Medicine, University of Belgrade , Belgrade, Serbia

[3] ³ Computational Bioscience Research Center (CBRC), King Abdullah University of Science and Technology (KAUST) , Thuwal, Saudi Arabia

[4] ⁴ Computer Science Program, Computer, Electrical and Mathematical Sciences and Engineering Division (CEMSE), King Abdullah University of Science and Technology (KAUST) , Thuwal, Saudi Arabia

Author notes

Edited by: Gaetano Santulli, Albert Einstein College of Medicine, United States

Reviewed by: Jörgen Isgaard, University of Gothenburg, Sweden; Pradeep Kumar Dabla, G B Pant Institute of Postgraduate Medical Education and Research (GIPMER), India

*Correspondence: Mirjana Macvanin, mirjana.macvanin@ 123456vin.bg.ac.rs

This article was submitted to Cardiovascular Endocrinology, a section of the journal Frontiers in Endocrinology

Article

DOI: 10.3389/fendo.2023.1142644

PMC ID: 9947133

SO-VID: e7dd06b3-ae8b-4cd9-bbd4-481e9a8fd90e

License:

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

History

Date received : 11 January 2023

Date accepted : 26 January 2023

Page count

Figures: 2, Tables: 0, Equations: 0, References: 229, Pages: 13, Words: 6386

Funding

This work is part of the collaboration between the Department of Radiobiology and Molecular Genetics, “VINČA” Institute of Nuclear Sciences - National Institute of the Republic of Serbia, University of Belgrade, Belgrade, Serbia, Clinic for Internal Medicine, Department of Endocrinology and Diabetes, Zemun Clinical Hospital, School of Medicine, University of Belgrade, Belgrade, Serbia, and KAUST. The research was funded by the Ministry of Education, Science and Technological Development of the Republic of Serbia (Contract No#451-03-9/2021-14/200017) and King Abdullah University of Science and Technology (KAUST) through grant awards Nos. BAS/1/1624-01-01, FCC/1/1976-20-01, FCC/1/1976-26-01, and Contract No#OSR 4129.

New insights on the cardiovascular effects of IGF-1

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Abstract

Introduction

Methods

Results

Discussion

Related collections

Bioscientifica Open Endocrinology

Most cited references 228

MicroRNAs: genomics, biogenesis, mechanism, and function.

The functions of animal microRNAs.

2015 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: Task Force for the Management of Acute Coronary Syndromes in Patients Presenting without Persistent ST-Segment Elevation of the European Society of Cardiology (ESC).

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