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Nuclear imaging of liposomal drug delivery systems: A critical review of radiolabelling methods and applications in nanomedicine
review-article
15 March 2019
Nanomedicine,
Drug delivery,
Liposome,
PET,
SPECT,
Nuclear imaging,
Theranostics,
[18F]FDP, 3-[18F]fluoro-1,2-dipalmitoylglycerol,
[18F]SteP2, 1-[18F]fluoro-3,6-dioxatetracosane,
%ID/g, percentage of the injected dose per gram of tissue,
2HQ, 2-hydroxyquinoline,
4-DEAP-ATSC, 4,4′-bis(3-(N,N-diethylamino)propyl)thiosemicarbazone,
ABC, accelerated blood clearance,
ADA, amino diatrizoic acid,
BAT, 6-[p-(bromoacetamido)benzyl]-1,4,8,11-tetraazacyclotetradecane-N,N′,N′′,N′′′-tetraacetic acid ,
BMEDA, N,N-bis(2-mercaptoethyl)-N’,N’-diethyl-ethylenediamine,
CB-TE2A, 4,11-bis(carboxymethyl)-1,4,8,11-tetraazabicyclo-(6.6.2)hexadecane,
CuAAC, copper-catalysed azide−alkyne cycloaddition reaction,
DFO, desferrioxamine,
DISIDA, diisopropyl iminodiacetic acid,
DSPE, distearoylphosphatidylethanolamine,
DOTA, 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid,
DPPE, 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine,
DTPA, diethylenetriaminepentaacetic acid,
HMPAO, hexamethylpropyleneamine oxime,
HSA, human serum albumin,
HYNIC, hydrazinonicotinic acid,
IAL, ionophore-assisted loading,
IgG, immunoglobulin G,
IVIVC, in vitro-in vivo correlation,
LAI, liposomal amikacin for inhalation,
LDL, low-density lipoprotein,
LE, labelling efficiencies,
LOX-1, lectin-like oxidized low-density lipoprotein receptor-1,
NODAGA, 1,4,7-triazacyclononane,1-glutaric acid-4,7-acetic acid,
NTA, nitrilotriacetic acid,
PEG, polyethylene glycol,
PFS, patient progression-free survival,
PLA, PEGylated liposomal alendronate,
RCY, radiochemical yield,
TCEP, tris(2-carboxylethyl)phosphine,
TETA, 1,4,8,11-tetraazacyclotetradecane-1,4,8,11-tetraacetic acid,
TSC, 99mTc-sulfur colloid
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Abstract
The integration of nuclear imaging with nanomedicine is a powerful tool for efficient development and clinical translation of liposomal drug delivery systems. Furthermore, it may allow highly efficient imaging-guided personalised treatments. In this article, we critically review methods available for radiolabelling liposomes. We discuss the influence that the radiolabelling methods can have on their biodistribution and highlight the often-overlooked possibility of misinterpretation of results due to decomposition in vivo. We stress the need for knowing the biodistribution/pharmacokinetics of both the radiolabelled liposomal components and free radionuclides in order to confidently evaluate the images, as they often share excretion pathways with intact liposomes ( e.g. phospholipids, metallic radionuclides) and even show significant tumour uptake by themselves ( e.g. some radionuclides). Finally, we describe preclinical and clinical studies using radiolabelled liposomes and discuss their impact in supporting liposomal drug development and clinical translation in several diseases, including personalised nanomedicine approaches.
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Author and article information
nanomedicine,drug delivery,liposome,pet,spect,nuclear imaging,theranostics,[18f]fdp, 3-[18f]fluoro-1,2-dipalmitoylglycerol,[18f]step2, 1-[18f]fluoro-3,6-dioxatetracosane,%id/g, percentage of the injected dose per gram of tissue,2hq, 2-hydroxyquinoline,4-deap-atsc, 4,4′-bis(3-(n,n-diethylamino)propyl)thiosemicarbazone,abc, accelerated blood clearance,ada, amino diatrizoic acid,bat, 6-[p-(bromoacetamido)benzyl]-1,4,8,11-tetraazacyclotetradecane-n,n′,n′′,n′′′-tetraacetic acid,bmeda, n,n-bis(2-mercaptoethyl)-n’,n’-diethyl-ethylenediamine,cb-te2a, 4,11-bis(carboxymethyl)-1,4,8,11-tetraazabicyclo-(6.6.2)hexadecane,cuaac, copper-catalysed azide−alkyne cycloaddition reaction,dfo, desferrioxamine,disida, diisopropyl iminodiacetic acid,dspe, distearoylphosphatidylethanolamine,dota, 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid,dppe, 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine,dtpa, diethylenetriaminepentaacetic acid,hmpao, hexamethylpropyleneamine oxime,hsa, human serum albumin,hynic, hydrazinonicotinic acid,ial, ionophore-assisted loading,igg, immunoglobulin g,ivivc, in vitro-in vivo correlation,lai, liposomal amikacin for inhalation,ldl, low-density lipoprotein,le, labelling efficiencies,lox-1, lectin-like oxidized low-density lipoprotein receptor-1,nodaga, 1,4,7-triazacyclononane,1-glutaric acid-4,7-acetic acid,nta, nitrilotriacetic acid,peg, polyethylene glycol,pfs, patient progression-free survival,pla, pegylated liposomal alendronate,rcy, radiochemical yield,tcep, tris(2-carboxylethyl)phosphine,teta, 1,4,8,11-tetraazacyclotetradecane-1,4,8,11-tetraacetic acid,tsc, 99mtc-sulfur colloid
nanomedicine, drug delivery, liposome, pet, spect, nuclear imaging, theranostics, [18f]fdp, 3-[18f]fluoro-1,2-dipalmitoylglycerol, [18f]step2, 1-[18f]fluoro-3,6-dioxatetracosane, %id/g, percentage of the injected dose per gram of tissue, 2hq, 2-hydroxyquinoline, 4-deap-atsc, 4,4′-bis(3-(n,n-diethylamino)propyl)thiosemicarbazone, abc, accelerated blood clearance, ada, amino diatrizoic acid, bat, 6-[p-(bromoacetamido)benzyl]-1,4,8,11-tetraazacyclotetradecane-n,n′,n′′,n′′′-tetraacetic acid, bmeda, n,n-bis(2-mercaptoethyl)-n’,n’-diethyl-ethylenediamine, cb-te2a, 4,11-bis(carboxymethyl)-1,4,8,11-tetraazabicyclo-(6.6.2)hexadecane, cuaac, copper-catalysed azide−alkyne cycloaddition reaction, dfo, desferrioxamine, disida, diisopropyl iminodiacetic acid, dspe, distearoylphosphatidylethanolamine, dota, 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid, dppe, 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine, dtpa, diethylenetriaminepentaacetic acid, hmpao, hexamethylpropyleneamine oxime, hsa, human serum albumin, hynic, hydrazinonicotinic acid, ial, ionophore-assisted loading, igg, immunoglobulin g, ivivc, in vitro-in vivo correlation, lai, liposomal amikacin for inhalation, ldl, low-density lipoprotein, le, labelling efficiencies, lox-1, lectin-like oxidized low-density lipoprotein receptor-1, nodaga, 1,4,7-triazacyclononane,1-glutaric acid-4,7-acetic acid, nta, nitrilotriacetic acid, peg, polyethylene glycol, pfs, patient progression-free survival, pla, pegylated liposomal alendronate, rcy, radiochemical yield, tcep, tris(2-carboxylethyl)phosphine, teta, 1,4,8,11-tetraazacyclotetradecane-1,4,8,11-tetraacetic acid, tsc, 99mtc-sulfur colloid