Expression levels of the mitochondrial IAP antagonists Smac/DIABLO and Omi/HtrA2 in clear-cell renal cell carcinomas and their prognostic value.

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Abstract

Numerous molecular parameters are thought to be implicated in renal cell carcinoma (RCC) tumor biology and may therefore reflect the malignant potential of individual tumors. Their investigation may thus help to improve the postoperative management of RCC patients. This study characterized the mRNA expression levels and evaluated the prognostic effect of the mitochondrial inhibitor of apoptosis antagonists Smac/DIABLO and Omi/HtrA2 in tumor tissue from clear-cell RCC patients.

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Journal

Journal ID (iso-abbrev): J. Cancer Res. Clin. Oncol.

Title: Journal of cancer research and clinical oncology

Publisher: Springer Nature

ISSN: 0171-5216

ISSN (Print): 0171-5216

Publication date (Electronic): May 2008

Volume: 134

Issue: 5

Affiliations

[1 ] Department of Urology, Charité--Universitätsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany. carsten.kempkensteffen@charite.de

Article

DOI: 10.1007/s00432-007-0317-7

PubMed ID: 17922292

SO-VID: ffb85f23-78ee-4f41-95fc-afffb6c8f763

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