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      Detection of various lung diseases including COVID-19 using extreme learning machine algorithm based on the features extracted from a lightweight CNN architecture

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          Abstract

          Around the world, several lung diseases such as pneumonia, cardiomegaly, and tuberculosis (TB) contribute to severe illness, hospitalization or even death, particularly for elderly and medically vulnerable patients. In the last few decades, several new types of lung-related diseases have taken the lives of millions of people, and COVID-19 has taken almost 6.27 million lives. To fight against lung diseases, timely and correct diagnosis with appropriate treatment is crucial in the current COVID-19 pandemic. In this study, an intelligent recognition system for seven lung diseases has been proposed based on machine learning (ML) techniques to aid the medical experts. Chest X-ray (CXR) images of lung diseases were collected from several publicly available databases. A lightweight convolutional neural network (CNN) has been used to extract characteristic features from the raw pixel values of the CXR images. The best feature subset has been identified using the Pearson Correlation Coefficient (PCC). Finally, the extreme learning machine (ELM) has been used to perform the classification task to assist faster learning and reduced computational complexity. The proposed CNN-PCC-ELM model achieved an accuracy of 96.22% with an Area Under Curve (AUC) of 99.48% for eight class classification. The outcomes from the proposed model demonstrated better performance than the existing state-of-the-art (SOTA) models in the case of COVID-19, pneumonia, and tuberculosis detection in both binary and multiclass classifications. For eight class classification, the proposed model achieved precision, recall and fi-score and ROC are 100%, 99%, 100% and 99.99% respectively for COVID-19 detection demonstrating its robustness. Therefore, the proposed model has overshadowed the existing pioneering models to accurately differentiate COVID-19 from the other lung diseases that can assist the medical physicians in treating the patient effectively.

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          The meaning and use of the area under a receiver operating characteristic (ROC) curve.

          A representation and interpretation of the area under a receiver operating characteristic (ROC) curve obtained by the "rating" method, or by mathematical predictions based on patient characteristics, is presented. It is shown that in such a setting the area represents the probability that a randomly chosen diseased subject is (correctly) rated or ranked with greater suspicion than a randomly chosen non-diseased subject. Moreover, this probability of a correct ranking is the same quantity that is estimated by the already well-studied nonparametric Wilcoxon statistic. These two relationships are exploited to (a) provide rapid closed-form expressions for the approximate magnitude of the sampling variability, i.e., standard error that one uses to accompany the area under a smoothed ROC curve, (b) guide in determining the size of the sample required to provide a sufficiently reliable estimate of this area, and (c) determine how large sample sizes should be to ensure that one can statistically detect differences in the accuracy of diagnostic techniques.
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            Measuring the accuracy of diagnostic systems.

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            Diagnostic systems of several kinds are used to distinguish between two classes of events, essentially "signals" and "noise". For them, analysis in terms of the "relative operating characteristic" of signal detection theory provides a precise and valid measure of diagnostic accuracy. It is the only measure available that is uninfluenced by decision biases and prior probabilities, and it places the performances of diverse systems on a common, easily interpreted scale. Representative values of this measure are reported here for systems in medical imaging, materials testing, weather forecasting, information retrieval, polygraph lie detection, and aptitude testing. Though the measure itself is sound, the values obtained from tests of diagnostic systems often require qualification because the test data on which they are based are of unsure quality. A common set of problems in testing is faced in all fields. How well these problems are handled, or can be handled in a given field, determines the degree of confidence that can be placed in a measured value of accuracy. Some fields fare much better than others.
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                Author and article information

                Journal
                Biocybern Biomed Eng
                Biocybern Biomed Eng
                Biocybernetics and Biomedical Engineering
                The Author(s). Published by Elsevier B.V. on behalf of Nalecz Institute of Biocybernetics and Biomedical Engineering of the Polish Academy of Sciences.
                0208-5216
                2391-467X
                26 June 2023
                26 June 2023
                Affiliations
                [a ]Department of Electrical & Computer Engineering, Rajshahi University of Engineering & Technology, Rajshahi 6204, Bangladesh
                [b ]Department of Computer Science & Engineering, Rajshahi University of Engineering & Technology, Rajshahi 6204, Bangladesh
                [c ]Department of Electrical & Electronic Engineering, Rajshahi University of Engineering & Technology, Rajshahi 6204, Bangladesh
                [d ]Department of Computer Science, University of York, Deramore Lane, Heslington, York YO10 5GH, UK
                [e ]Department of Engineering, Manchester Metropolitan University, Chester St, Manchester M1 5GD, UK
                [f ]Institute of Optoelectronics, Military University of Technology, Gen. S. Kaliskiego 2, Warsaw, Poland
                Author notes
                [* ]Corresponding author at: Military University of Technology, Warsaw, Poland.
                Article
                S0208-5216(23)00037-2
                10.1016/j.bbe.2023.06.003
                10292668
                ff53cb4a-a62a-4e8b-99bb-b62e62c7f3f0
                © 2023 The Author(s)

                Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

                History
                : 18 December 2022
                : 4 April 2023
                : 16 June 2023
                Categories
                Original Research Article

                covid-19,convolutional neural network,extreme learning machine,pearson correlation coefficient,pneumonia

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