Strategies in the design of nanoparticles for therapeutic applications. – ScienceOpen
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      Strategies in the design of nanoparticles for therapeutic applications.

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          Abstract

          Engineered nanoparticles have the potential to revolutionize the diagnosis and treatment of many diseases; for example, by allowing the targeted delivery of a drug to particular subsets of cells. However, so far, such nanoparticles have not proved capable of surmounting all of the biological barriers required to achieve this goal. Nevertheless, advances in nanoparticle engineering, as well as advances in understanding the importance of nanoparticle characteristics such as size, shape and surface properties for biological interactions, are creating new opportunities for the development of nanoparticles for therapeutic applications. This Review focuses on recent progress important for the rational design of such nanoparticles and discusses the challenges to realizing the potential of nanoparticles.

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          Author and article information

          Journal
          Nat Rev Drug Discov
          Nature reviews. Drug discovery
          Springer Science and Business Media LLC
          1474-1784
          1474-1776
          Aug 2010
          : 9
          : 8
          Affiliations
          [1 ] Department of Chemistry, University of North Texas, Denton, Texas 76203, USA. petros@unt.edu
          Article
          nrd2591
          10.1038/nrd2591
          20616808
          ff182ac6-1e9e-4fe4-b083-c6d14e2da781
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