The generalizability of bronchiectasis randomized controlled trials: A multicentre cohort study.

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Abstract

Randomized controlled trials (RCTs) for bronchiectasis have experienced difficulties with recruitment and in reaching their efficacy end-points. To estimate the generalizability of such studies we applied the eligibility criteria for major RCTs in bronchiectasis to 6 representative observational European Bronchiectasis cohorts.

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Author and article information

Journal

Journal ID (iso-abbrev): Respir Med

Title: Respiratory medicine

Publisher: Elsevier BV

ISSN (Electronic): 1532-3064

ISSN (Print): 0954-6111

Publication date (Electronic): Mar 2016

Volume: 112

Affiliations

[1 ] Scottish Centre for Respiratory Research, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK. Electronic address: jchalmers@dundee.ac.uk.

[2 ] Department of Respiratory Medicine, Galway University Hospitals, Newcastle Road, Galway, Ireland.

[3 ] Institute of Cellular Medicine, Newcastle University and Adult Bronchiectasis Service Freeman Hospital Newcastle upon Tyne NE7 7DN, UK.

[4 ] Scottish Centre for Respiratory Research, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK.

[5 ] University Hospital Gasthuisberg, Respiratory Medicine, Herestraat 49, B-3000 Leuven, Belgium.

[6 ] Department of Respiratory Medicine, Royal Infirmary of Edinburgh and the University of Edinburgh, 51 Little France Crescent, Old Dalkeith Road, Edinburgh, EH16 4SA, UK.

[7 ] Department of Health Science, University of Milan Bicocca, Clinica Pneumologica, AO San Gerardo, Via Pergolesi 33, Monza, Italy.

[8 ] University Hospital Gasthuisberg, Respiratory Medicine, Herestraat 49, B-3000 Leuven, Belgium; Department of Respiratory Medicine, AZ Nikolaas, Sint-Niklaas, Belgium.

Article

Publisher Item ID: S0954-6111(16)30012-9

DOI: 10.1016/j.rmed.2016.01.016

PubMed ID: 26856192

SO-VID: fc8b1b75-2c42-415e-a847-20b5f5ff92f8

History

Keywords: Evidence-based medicine,Antibiotics,Bronchiectasis,Clinical trials

Data availability:

Keywords: Evidence-based medicine, Antibiotics, Bronchiectasis, Clinical trials

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