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Long-term macrolide antibiotics for the treatment of bronchiectasis in adults: an individual participant data meta-analysis
James D Chalmers ,
Wim Boersma ,
Mike Lonergan ,
Lata Jayaram ,
Megan L Crichton ,
Noel Karalus ,
Steven L Taylor ,
Megan L Martin ,
Lucy D Burr ,
Conroy Wong ,
Josje Altenburg
August 2019
August 2019
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Abstract
Bronchiectasis guidelines recommend long-term macrolide treatment for patients with
three or more exacerbations per year without Pseudomonas aeruginosa infection. Randomised
controlled trials suggest that long-term macrolide treatment can prevent exacerbations
in adult patients with bronchiectasis, but these individual studies have been too
small to do meaningful subgroup analyses. We did a systematic review and individual
patient data (IPD) meta-analysis to explore macrolide benefit in subpopulations, including
those in which macrolide therapy is not currently recommended.