Does Occupational Exposure to Organic Solvents Affect Colour Discrimination? :

Neurobiology of retinal dopamine is reviewed and discussed in relation to degenerative states of the tissue. The Introduction deals with the basic physiological actions of dopamine on the different neurons in vertebrate retinae with an emphasis upon mammals. The intimate relationship between the dopamine and melatonin systems is also covered. Recent advances in the molecular biology of dopamine receptors is reviewed in some detail. As degenerative states of the retina, three examples are highlighted: Parkinson's disease; ageing; and retinal dystrophy (retinitis pigmentosa). As visual functions controlled, at least in part, by dopamine, absolute sensitivity, spatial contrast sensitivity, temporal (including flicker) sensitivity and colour vision are reviewed. Possible cellular and synaptic bases of the visual dysfunctions observed during retinal degenerations are discussed in relation to dopaminergic control. It is concluded that impairment of the dopamine system during retinal degenerations could give rise to many of the visual abnormalities observed. In particular, the involvement of dopamine in controlling the coupling of horizontal and amacrine cell lateral systems appears to be central to the visual defects seen.

To provide normative data for chromatic discrimination on the Farnsworth-Munsell 100 hue test particularly for observers under 23 years of age. Normal observers were screened for congenital colour vision deficiencies using the Ishihara test leaving 382 observers. New total error score (TES) norms (means and 95th percentiles) are presented for each year of age from 5-22 and for 10 year age groups from the 30s to the 70s. These norms are presented as actual values (TES) and also as square root values ( radical TES). Other data include partial error scores for red-green and blue-yellow axes discrimination. This study provides the most detailed set of normative data to date. The data are also in agreement with other reports of chromatic discrimination, showing that the performance in this task varies as a U-shape function with age, the best being achieved at 19 years of age.

The Farnsworth Dichotomous test or Panel D-15 is used extensively for the evaluation of colour discrimination in congenital and acquired colour vision defects. This qualitative assessment of colour vision defect type and severity is based on the hue confusions which are represented diagrammatically on the Panel D-15 score sheet. This paper presents a new proposal for quantitatively scoring the Panel D-15 based on those hue confusions made by the subject. Such a quantitative score can be used to establish relationships with other visual functions or experimental conditions. The application of the scoring technique to clinical results is illustrated.