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      Pot economy and one-pot synthesis

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      Journal: Chemical Science
      Publisher: Royal Society of Chemistry

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          Abstract

          This review describes the importance and usefulness of pot-economy and one-pot reactions in current synthetic organic chemistry.

          Abstract

          The one-pot synthesis of a target molecule in the same reaction vessel is widely considered to be an efficient approach in synthetic organic chemistry. In this review, the characteristics and limitations of various one-pot syntheses of biologically active molecules are explained, primarily involving organocatalytic methods as key tactics. Besides catalysis, the pot-economy concepts presented herein are also applicable to organometallic and organic reaction methods in general.

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          Organocatalytic cascade reactions as a new tool in total synthesis.

          Christoph Grondal, Matthieu Jeanty, Dieter Enders … (2010)
          The total synthesis of natural products and biologically active compounds, such as pharmaceuticals and agrochemicals, has reached an extraordinary level of sophistication. We are, however, still far away from the 'ideal synthesis' and the state of the art is still frequently hampered by lengthy protecting-group strategies and costly purification procedures derived from the step-by-step protocols. In recent years several new criteria have been brought forward to solve these problems and to improve total synthesis: atom, step and redox economy or protecting-group-free synthesis. Over the past decade the research area of organocatalysis has rapidly grown to become a third pillar of asymmetric catalysis standing next to metal and biocatalysis, thus paving the way for a new and powerful strategy that can help to address these issues - organocatalytic cascade reactions. In this Review we present the first applications of such asymmetric organocascade reactions to the total synthesis of natural products.
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            The economies of synthesis.

            Timothy Newhouse, Phil S. Baran, Reinhard W Hoffmann … (2009)
            In this tutorial review the economies of synthesis are analysed from both detailed and macroscopic perspectives, using case-studies from complex molecule synthesis. Atom, step, and redox economy are more than philosophical constructs, but rather guidelines, which enable the synthetic chemist to design and execute an efficient synthesis. Students entering the field of synthesis might find this tutorial helpful for understanding the subtle differences between these economic principles and also see real-world situations where such principles are put into practice.
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              Tandem [4+2]/[3+2] Cycloadditions of Nitroalkenes.

              Atli Thorarensen, Scott Denmark (1996)
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                Author and article information

                Journal
                Journal ID (nlm-ta): Chem Sci
                Journal ID (iso-abbrev): Chem Sci
                Title: Chemical Science
                Publisher: Royal Society of Chemistry
                ISSN (Print): 2041-6520
                ISSN (Electronic): 2041-6539
                Publication date (Print): 1 February 2016
                Publication date (Electronic): 6 January 2016
                Volume: 7
                Issue: 2
                Pages: 866-880
                Affiliations
                [a ] Department of Chemistry , Graduate School of Science , Tohoku University , 6-3 Aramaki-Aza Aoba, Aoba-ku , Sendai 980-8578 , Japan . Email: yhayashi@ 123456m.tohoku.ac.jp ; Fax: +81-22-795-6566 ; Tel: +81-22-795-3554
                Article
                Publisher ID: c5sc02913a
                DOI: 10.1039/c5sc02913a
                PMC ID: 5529999
                PubMed ID: 28791118
                SO-VID: fbb2a427-e2b5-4db2-9c5c-bf84f67725bf
                Copyright © This journal is © The Royal Society of Chemistry 2016
                License:

                This is an Open Access article distributed under the terms of the Creative Commons Attribution 3.0 Unported License ( http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                Date received : 7 August 2015
                Date accepted : 26 November 2015
                Categories
                Subject: Chemistry

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