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      Developments in diagnosis and treatment of paediatric septic arthritis

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          Abstract

          Acute septic arthritis in children is an orthopaedic emergency. A delay in diagnosis and inappropriate treatment can result in devastating damage to the joint with lifelong disability as a consequence. The clinical presentation can be a diagnostic challenge, especially in young children. A recent systematic review showed that joint tenderness and fever are important signals of septic arthritis. Ultrasound is helpful in detecting the presence of a joint effusion. Plain radiographs may show bone changes but magnetic resonance imaging is the most reliable imaging study for detecting concomitant osteomyelitis. The diagnosis of acute septic arthritis is highly suggestive when pus is aspirated from the joint, in case of a positive culture or a positive gram stain of the joint fluid, or if there is a white blood-cell count in the joint fluid of more than 50000/mm 3. Staphylococcus aureus is the most commonly cultured organism. Recent systematic reviews have identified the most effective drainage techniques, including needle aspiration, arthroscopy and arthrotomy, depending on the affected joint. After the drainage procedure it is important to monitor the clinical and laboratory outcomes. Additional drainage procedures may be necessary in select cases.

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          Haematogenous acute and subacute paediatric osteomyelitis: a systematic review of the literature.

          A delay in the diagnosis of paediatric acute and subacute haematogenous osteomyelitis can lead to potentially devastating morbidity. There are no definitive guidelines for diagnosis, and recommendations in the literature are generally based on expert opinions, case series and cohort studies. All articles in the English literature on paediatric osteomyelitis were searched using MEDLINE, CINAHL, EMBASE, Google Scholar, the Cochrane Library and reference lists. A total of 1854 papers were identified, 132 of which were examined in detail. All aspects of osteomyelitis were investigated in order to formulate recommendations. On admission 40% of children are afebrile. The tibia and femur are the most commonly affected long bones. Clinical examination, blood and radiological tests are only reliable for diagnosis in combination. Staphylococcus aureus is the most common organism detected, but isolation of Kingella kingae is increasing. Antibiotic treatment is usually sufficient to eradicate the infection, with a short course intravenously and early conversion to oral treatment. Surgery is indicated only in specific situations. Most studies were retrospective and there is a need for large, multicentre, randomised, controlled trials to define protocols for diagnosis and treatment. Meanwhile, evidence-based algorithms are suggested for accurate and early diagnosis and effective treatment.
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            PRIMARY PYOMYOSITIS

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              A study of classification criteria for a diagnosis of juvenile rheumatoid arthritis.

              Criteria for the classification of juvenile rheumatoid arthritis were analyzed in a detailed database of 250 children in order to assess the accuracy of diagnosis and validity of onset types and course subtypes. A number of conclusions have been derived from this study: All definitions of the 1973 criteria for classification of juvenile rheumatoid arthritis should be retained. The addition of onset types to the 1976 revision of the criteria has been validated. The course of the disease after the onset period of 6 months is as important to the outcome of a group of children as is the onset type. The current classification should be broadened to include the course subtypes.
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                Author and article information

                Contributors
                Journal
                World J Orthop
                WJO
                World Journal of Orthopedics
                Baishideng Publishing Group Inc
                2218-5836
                18 February 2022
                18 February 2022
                : 13
                : 2
                : 122-130
                Affiliations
                Department of Orthopaedic Surgery, Meander Medical Centre, Amersfoort 3813 TZ, Netherlands. lilian.donders@ 123456gmail.com
                Department of Orthopaedic Surgery, Sint Maartenskliniek, Nijmegen 6574 NA, Netherlands
                Department of Paediatrics, Amphia Hospital, Breda 4818 CK, Netherlands
                Department of Orthopedic Surgery, Amphia Hospital, Breda 4818 CK, Netherlands
                Author notes

                Author contributions: Donders CM contributed to the conceptualization; study-selection; data extraction; data analysis; writing of the manuscript; Spaans AJ and van Wering H critically revised the manuscript; van Bergen CJ contributed to the conceptualization; supervision; writing of the manuscript.

                Corresponding author: Cornelia M Donders, MD, MSc, Academic Research, Department of Orthopaedic Surgery, Meander Medical Centre, Maatweg 3, Amersfoort 3813 TZ, Netherlands. lilian.donders@ 123456gmail.com

                Article
                jWJO.v13.i2.pg122
                10.5312/wjo.v13.i2.122
                8891656
                35317401
                fa79fed6-0189-4cfa-b201-80df873e19ce
                ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.

                This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

                History
                : 26 February 2021
                : 8 August 2021
                : 20 January 2022
                Categories
                Minireviews

                septic arthritis,paediatric,children,analysis,treatment,drainage

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