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      An update on recent progress of the epidemiology, etiology, diagnosis, and treatment of acute septic arthritis: a review

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          Abstract

          Acute septic arthritis is on the rise among all patients. Acute septic arthritis must be extensively assessed, identified, and treated to prevent fatal consequences. Antimicrobial therapy administered intravenously has long been considered the gold standard for treating acute osteoarticular infections. According to clinical research, parenteral antibiotics for a few days, followed by oral antibiotics, are safe and effective for treating infections without complications. This article focuses on bringing physicians up-to-date on the most recent findings and discussions about the epidemiology, etiology, diagnosis, and treatment of acute septic arthritis. In recent years, the emergence of antibiotic-resistant, particularly aggressive bacterial species has highlighted the need for more research to enhance treatment approaches and develop innovative diagnosis methods and drugs that might combat better in all patients. This article aims to furnish radiologists, orthopaedic surgeons, and other medical practitioners with contemporary insights on the subject matter and foster collaborative efforts to improve patient outcomes. This review represents the initial comprehensive update encompassing patients across all age groups.

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          Most cited references97

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          A Novel Coronavirus from Patients with Pneumonia in China, 2019

          Summary In December 2019, a cluster of patients with pneumonia of unknown cause was linked to a seafood wholesale market in Wuhan, China. A previously unknown betacoronavirus was discovered through the use of unbiased sequencing in samples from patients with pneumonia. Human airway epithelial cells were used to isolate a novel coronavirus, named 2019-nCoV, which formed a clade within the subgenus sarbecovirus, Orthocoronavirinae subfamily. Different from both MERS-CoV and SARS-CoV, 2019-nCoV is the seventh member of the family of coronaviruses that infect humans. Enhanced surveillance and further investigation are ongoing. (Funded by the National Key Research and Development Program of China and the National Major Project for Control and Prevention of Infectious Disease in China.)
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            The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3).

            Definitions of sepsis and septic shock were last revised in 2001. Considerable advances have since been made into the pathobiology (changes in organ function, morphology, cell biology, biochemistry, immunology, and circulation), management, and epidemiology of sepsis, suggesting the need for reexamination.
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              Clinical Metagenomic Next-Generation Sequencing for Pathogen Detection

              Nearly all infectious agents contain DNA or RNA genomes, making sequencing an attractive approach for pathogen detection. The cost of high-throughput or next-generation sequencing has been reduced by several orders of magnitude since its advent in 2004, and it has emerged as an enabling technological platform for the detection and taxonomic characterization of microorganisms in clinical samples from patients. This review focuses on the application of untargeted metagenomic next-generation sequencing to the clinical diagnosis of infectious diseases, particularly in areas in which conventional diagnostic approaches have limitations. The review covers ( a) next-generation sequencing technologies and common platforms, ( b) next-generation sequencing assay workflows in the clinical microbiology laboratory, ( c) bioinformatics analysis of metagenomic next-generation sequencing data, ( d) validation and use of metagenomic next-generation sequencing for diagnosing infectious diseases, and ( e) significant case reports and studies in this area. Next-generation sequencing is a new technology that has the promise to enhance our ability to diagnose, interrogate, and track infectious diseases.
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                Author and article information

                Contributors
                Journal
                Front Cell Infect Microbiol
                Front Cell Infect Microbiol
                Front. Cell. Infect. Microbiol.
                Frontiers in Cellular and Infection Microbiology
                Frontiers Media S.A.
                2235-2988
                02 May 2023
                2023
                : 13
                : 1193645
                Affiliations
                [1] 1 Department of Orthopaedics, Xiangya Hospital, Central South University , Changsha, Hunan, China
                [2] 2 National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University , Changsha, Hunan, China
                [3] 3 Department of Emergency Medicine, Xiangya Hospital, Central South University , Changsha, Hunan, China
                Author notes

                Edited by: Chaofan Zhang, First Affiliated Hospital of Fujian Medical University, China

                Reviewed by: Anna Benini, University of Verona, Italy; Chengzhen Liang, Zhejiang University, China

                *Correspondence: Bangbao Lu, 14182832@ 123456qq.com ; Fangjie Zhang, zhangfj@ 123456csu.edu.cn

                †These authors have contributed equally to this work and share first authorship

                Article
                10.3389/fcimb.2023.1193645
                10214960
                37249986
                fa93f540-182f-46c1-b86a-943f538428cb
                Copyright © 2023 He, Arthur Vithran, Pan, Zeng, Yang, Lu and Zhang

                This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

                History
                : 25 March 2023
                : 20 April 2023
                Page count
                Figures: 2, Tables: 1, Equations: 0, References: 98, Pages: 10, Words: 5147
                Funding
                Funded by: National Natural Science Foundation of China , doi 10.13039/501100001809;
                This study was supported by the National Natural Science Foundation of China (81501023, 81874034, 81902303), the Rui E (Ruiyi) Emergency Medical Research Special Funding Project(No.R2019007) and the Natural Science Foundation of Changsha City (No.kq2208380).
                Categories
                Cellular and Infection Microbiology
                Review
                Custom metadata
                Clinical Microbiology

                Infectious disease & Microbiology
                septic arthritis,pathogenic microorganism,antibiotics,arthroscopy,epidemiology

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