Advances in the molecular mechanisms of zinc-finger transcription factors in neurodevelopmental disorders

Abstract

Neurodevelopmental disorders (NDDs) constitute a heterogeneous group of early-onset brain dysfunction disorders, which may arise from genetic or acquired etiologies. These disorders are characterized by behavioral and cognitive deficits that predominantly manifest during childhood development, thereby potentially impairing an individual's performance in learning, sports, and social situations. A comprehensive understanding of the pathogenesis of NDDs is crucial for the development of targeted therapeutic interventions. Zinc-finger transcription factors (ZFPs) play a pivotal role in regulating gene expression by modulating the binding of RNA polymerase to DNA, thereby either activating or repressing gene transcription. In recent years, the BCL11 gene family of ZFPs has garnered significant attention due to its critical involvement in nervous system development. This review aims to elucidate the structure and molecular functions of the BCL11 gene family, discuss its impact on the development of the central nervous system, and explore its association with neurodevelopmental disorders.