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      Antimicrobial Susceptibility Testing for Corynebacterium Species Isolated from Clinical Samples in Romania

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          Abstract

          Antimicrobial resistance is one of the most important public health issues. Besides classical multidrug resistance species associated with medical care involved in superficial or invasive infections, there are strains less commonly associated with hospital or outpatient setting’s infections. Non-diphtheria Corynebacterium spp. could produce infections in patients with or without immune-compromised status. The aim of our study was to determine the susceptibility to antimicrobial agents to Corynebacterium spp. from clinical samples collected from Romanian hospitalized individuals and outpatients. Twenty Corynebacterium strains were isolated and identified as Corynebacterium striatum ( n = 7), Corynebacterium amycolatum ( n = 7), C. urealyticum ( n = 3), Corynebacterium afermentans ( n = 2), and Corynebacterium pseudodiphtheriticum ( n = 1). All isolates have been tested for antibiotic susceptibility by standardized disc diffusion method and minimal inhibitory concentration (MIC) tests. Seventeen isolates demonstrated multidrug resistance phenotypes. The molecular support responsible for high resistance to quinolones for ten of these strains was determined by the detection of point mutation in the gene sequence gyrA.

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          Clinical microbiology of coryneform bacteria.

          G Funke, A von Graevenitz, J Clarridge … (1997)
          Coryneform bacteria are aerobically growing, asporogenous, non-partially-acid-fast, gram-positive rods of irregular morphology. Within the last few years, there has been a massive increase in the number of publications related to all aspects of their clinical microbiology. Clinical microbiologists are often confronted with making identifications within this heterogeneous group as well as with considerations of the clinical significance of such isolates. This review provides comprehensive information on the identification of coryneform bacteria and outlines recent changes in taxonomy. The following genera are covered: Corynebacterium, Turicella, Arthrobacter, Brevibacterium, Dermabacter. Propionibacterium, Rothia, Exiguobacterium, Oerskovia, Cellulomonas, Sanguibacter, Microbacterium, Aureobacterium, "Corynebacterium aquaticum," Arcanobacterium, and Actinomyces. Case reports claiming disease associations of coryneform bacteria are critically reviewed. Minimal microbiological requirements for publications on disease associations of coryneform bacteria are proposed.
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            Occurrence of Corynebacterium striatum as an emerging antibiotic-resistant nosocomial pathogen in a Tunisian hospital

            Sana Alibi, Asma Ferjani, Jalel Boukadida … (2017)
            Corynebacterium striatum is a nosocomial opportunistic pathogen increasingly associated with a wide range of human infections and is often resistant to several antibiotics. We investigated the susceptibility of 63 C. striatum isolated at the Farhat-Hached hospital, Sousse (Tunisia), during the period 2011–2014, to a panel of 16 compounds belonging to the main clinically relevant classes of antimicrobial agents. All strains were susceptible to vancomycin, linezolid, and daptomycin. Amikacin and gentamicin also showed good activity (MICs90 = 1 and 2 mg/L, respectively). High rates of resistance to penicillin (82.5%), clindamycin (79.4%), cefotaxime (60.3%), erythromycin (47.6%), ciprofloxacin (36.5%), moxifloxacin (34.9%), and rifampicin (25.4%) were observed. Fifty-nine (93.7%) out of the 63 isolates showed resistance to at least one compound and 31 (49.2%) were multidrug-resistant. Twenty-nine resistance profiles were distinguished among the 59 resistant C. striatum. Most of the strains resistant to fluoroquinolones showed a double mutation leading to an amino acid change in positions 87 and 91 in the quinolone resistance-determining region of the gyrA gene. The 52 strains resistant to penicillin were positive for the gene bla, encoding a class A β-lactamase. Twenty-two PFGE patterns were identified among the 63 C. striatum, indicating that some clones have spread within the hospital.
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              Big Data, Internet of Things and Cloud Convergence – An Architecture for Secure E-Health Applications

              George Suciu, Victor Suciu, Alexandru Martian … (2015)
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                Author and article information

                Journal
                Journal ID (nlm-ta): Antibiotics (Basel)
                Journal ID (iso-abbrev): Antibiotics (Basel)
                Journal ID (publisher-id): antibiotics
                Title: Antibiotics
                Publisher: MDPI
                ISSN (Electronic): 2079-6382
                Publication date (Electronic): 16 January 2020
                Publication date Collection: January 2020
                Volume: 9
                Issue: 1
                Electronic Location Identifier: 31
                Affiliations
                [1 ]“Cantacuzino” National Medico Military Institute for Research and Development, 050096 Bucharest, Romania; ceraseladragomirescu@ 123456yahoo.com (C.C.D.); brandusa_lixandru@ 123456yahoo.com (B.E.L.); luminitacoldea@ 123456yahoo.com (I.L.C.); olgutza_dracea@ 123456yahoo.co.uk (O.N.C.); marina.pana@ 123456yahoo.com (M.P.); print_andi@ 123456yahoo.com (A.M.P.); mircea.ioan.popa@ 123456gmail.com (M.I.P.)
                [2 ]“Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, Romania; dr.gabriela.popa@ 123456gmail.com
                [3 ]Central Reference Laboratory Synevo, 021408 Bucharest, Romania; violeta.cristea@ 123456synevo.ro
                [4 ]BEIA Consult International, Peroni 16, 041386 Bucharest, Romania; ioana.suciu@ 123456beia.ro (I.S.); george@ 123456beia.ro (G.S.)
                [5 ]Colentina Clinical Hospital (CDPC), 020125 Bucharest, Romania
                Author notes
                [* ]Correspondence: loredana.manolescu@ 123456umfcd.ro ; Tel.: +40-723-699-253
                Author information
                https://orcid.org/0000-0001-8694-6195
                https://orcid.org/0000-0002-0794-9329
                Article
                Publisher ID: antibiotics-09-00031
                DOI: 10.3390/antibiotics9010031
                PMC ID: 7168242
                PubMed ID: 31963167
                SO-VID: f825963a-dba6-46e7-959f-16712db9d8c9
                Copyright © © 2020 by the authors.
                License:

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/).

                History
                Date received : 10 December 2019
                Date accepted : 14 January 2020
                Categories
                Subject: Article

                Keywords: corynebacterium spp.,antimicrobial susceptibility testing,multidrug resistance phenotypes
                Data availability:
                Keywords: corynebacterium spp., antimicrobial susceptibility testing, multidrug resistance phenotypes

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