The treatment outcomes of nanomedicines against colorectal cancer are severely restricted by their insufficient accumulation in the tumor tissues, unsatisfactory antitumor effect, and weak immunometabolic modulation. To address these issues, flying‐saucer‐shaped nanoheterojunctions by coating copper oxide (Cu xO) onto the surface of PEGylated zinc oxide (ZnO) nanoparticles are constructed. When exposed to ultrasound, the resultant Cu xO@ZnO nanoheterojunctions exhibit increased locomotor activities, facilitating colorectal mucus infiltration, deep tumor penetration, and tumor cell internalization. The decoration of Cu xO suppresses the rapid recombination of electrons and holes in Cu xO@ZnO exposed to ultrasound, promoting the production of singlet oxygen and hydroxyl radical, which are generated by Cu xO through a Fenton‐like chemodynamic reaction and Cu xO@ZnO through sonodynamic reaction. After rectal administration, the sono‐chemodynamic Cu xO@ZnO plus PD‐L1 antibodies effectively inhibit the growth of orthotopic and distant tumors. It elicits immunometabolic responses by inducing immunogenic cell death, activating the interferon genes signaling pathway stimulator, and inhibiting glucose transport and the glycolytic signaling pathways. This combined modality also increases the proportion of beneficial microbes ( e.g., Bifidobacterium) and decreases the abundance of harmful microorganisms ( e.g., Romboutsia) in the intestine. This treatment modality (Cu xO@ZnO plus ultrasound and PD‐L1 antibodies) is a promising strategy for the synergistic treatment of colorectal cancer.
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