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      Prospective health care costs and lost work days associated with diabetes-related distress and depression symptoms among 1488 individuals with diabetes

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          Abstract

          The aim of this study was to investigating the impact of major depression symptoms and diabetes-related distress on future health care costs and lost workdays in individuals with diabetes. We linked survey data from a random sample of a German statutory health insurance (SHI) with diabetes (n = 1488, 63.0% male, mean age 66.9 years) with their SHI data one year after the survey. Within the survey data we identified major depression symptoms (Patient Health Questionnaire-9) and diabetes-related distress (Problem Areas in Diabetes Scale). We retrieved health care costs and lost workdays from SHI data. To assess the impact of major depression symptoms and diabetes-related distress on health care costs and lost workdays, we adjusted regression models for age, sex, education, employment status, and diabetes duration, type, and severity. Major depression symptoms were associated with significantly higher costs (by a factor of 1.49; 95% CI: 1.18–1.88). Lost workdays were also more likely for respondents with depression symptoms (RR1.34; 0.97–1.86). Health care costs (by a factor of 0.81; 0.66–1.01) and the risk of lost workdays (RR 0.86; 0.62–1.18) may be lower among respondents with high diabetes-related distress. While major depression and diabetes-related distress have overlapping indicators, our results indicate different impacts on health care costs.

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          The PHQ-9: validity of a brief depression severity measure.

          While considerable attention has focused on improving the detection of depression, assessment of severity is also important in guiding treatment decisions. Therefore, we examined the validity of a brief, new measure of depression severity. The Patient Health Questionnaire (PHQ) is a self-administered version of the PRIME-MD diagnostic instrument for common mental disorders. The PHQ-9 is the depression module, which scores each of the 9 DSM-IV criteria as "0" (not at all) to "3" (nearly every day). The PHQ-9 was completed by 6,000 patients in 8 primary care clinics and 7 obstetrics-gynecology clinics. Construct validity was assessed using the 20-item Short-Form General Health Survey, self-reported sick days and clinic visits, and symptom-related difficulty. Criterion validity was assessed against an independent structured mental health professional (MHP) interview in a sample of 580 patients. As PHQ-9 depression severity increased, there was a substantial decrease in functional status on all 6 SF-20 subscales. Also, symptom-related difficulty, sick days, and health care utilization increased. Using the MHP reinterview as the criterion standard, a PHQ-9 score > or =10 had a sensitivity of 88% and a specificity of 88% for major depression. PHQ-9 scores of 5, 10, 15, and 20 represented mild, moderate, moderately severe, and severe depression, respectively. Results were similar in the primary care and obstetrics-gynecology samples. In addition to making criteria-based diagnoses of depressive disorders, the PHQ-9 is also a reliable and valid measure of depression severity. These characteristics plus its brevity make the PHQ-9 a useful clinical and research tool.
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            WITHDRAWN: Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: results from the International Diabetes Federation Diabetes Atlas, 9th edition

            To provide global estimates of diabetes prevalence for 2019 and projections for 2030 and 2045.
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              A modified poisson regression approach to prospective studies with binary data.

              G Zou (2004)
              Relative risk is usually the parameter of interest in epidemiologic and medical studies. In this paper, the author proposes a modified Poisson regression approach (i.e., Poisson regression with a robust error variance) to estimate this effect measure directly. A simple 2-by-2 table is used to justify the validity of this approach. Results from a limited simulation study indicate that this approach is very reliable even with total sample sizes as small as 100. The method is illustrated with two data sets.
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                Author and article information

                Contributors
                ute.linnenkamp@ddz.de
                Journal
                Sci Rep
                Sci Rep
                Scientific Reports
                Nature Publishing Group UK (London )
                2045-2322
                13 February 2024
                13 February 2024
                2024
                : 14
                : 3621
                Affiliations
                [1 ]Institute for Health Services Research and Health Economics, German Diabetes Center (DDZ), Düsseldorf at the Heinrich-Heine University Düsseldorf, Leibniz Center for Diabetes Research at the Heinrich Heine University, ( https://ror.org/04ews3245) Auf’m Hennekamp 65, 40225 Duesseldorf, Germany
                [2 ]Institute for Health Services Research and Health Economics, Centre for Health and Society, Medical Faculty, Heinrich Heine University, ( https://ror.org/024z2rq82) Moorenstraße 5, 40225 Duesseldorf, Germany
                [3 ]German Center for Diabetes Research (DZD), ( https://ror.org/04qq88z54) Ingolstaedter Landstraße 1, 85764 Neuherberg, Germany
                [4 ]Department of Health Services Research, CAPHRI Care and Public Health Research Institute, Maastricht University, ( https://ror.org/02jz4aj89) Maastricht, The Netherlands
                [5 ]Pronova BKK, Statutory Health Insurance, 67058 Ludwigshafen, Germany
                [6 ]GRID grid.411067.5, ISNI 0000 0000 8584 9230, Clinic for Psychosomatic and Psychotherapy, , University Clinic Gießen, ; Friedrichstraße 33, 35392 Gießen, Germany
                [7 ]Trimbos Institute, Netherlands Institute of Mental Health and Addiction, ( https://ror.org/02amggm23) Utrecht, the Netherlands
                [8 ]Institute for Occupational, Social and Environmental Medicine, Centre for Health and Society, Faculty of Medicine, Heinrich-Heine University Düsseldorf, ( https://ror.org/024z2rq82) Gurlittstr. 55/II, 40223 Düsseldorf, Germany
                Article
                52361
                10.1038/s41598-024-52361-4
                10864264
                38351084
                f581dcd2-e13a-48ed-a5ae-bab23f05c065
                © The Author(s) 2024

                Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

                History
                : 28 November 2023
                : 17 January 2024
                Funding
                Funded by: German Federal Ministry of Education and Research
                Award ID: No. 01GY1133
                Award Recipient :
                Categories
                Article
                Custom metadata
                © Springer Nature Limited 2024

                Uncategorized
                diabetes complications,epidemiology
                Uncategorized
                diabetes complications, epidemiology

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