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      Hidden consequences of olfactory dysfunction: a patient report series

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          Abstract

          Background

          The negative consequences of olfactory dysfunction for the quality of life are not widely appreciated and the condition is therefore often ignored or trivialized.

          Methods

          1,000 patients with olfactory dysfunction participated in an online study by submitting accounts of their subjective experiences of how they have been affected by their condition. In addition, they were given the chance to answer 43 specific questions about the consequences of their olfactory dysfunction.

          Results

          Although there are less practical problems associated with impaired or distorted odor perception than with impairments in visual or auditory perception, many affected individuals report experiencing olfactory dysfunction as a debilitating condition. Smell loss-induced social isolation and smell loss-induced anhedonia can severely affect quality of life.

          Conclusions

          Olfactory dysfunction is a serious condition for those affected by it and it deserves more attention from doctors who treat affected patients as well as from scientist who research treatment options.

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          Most cited references156

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          Reconsidering anhedonia in depression: lessons from translational neuroscience.

          Anhedonia is a core symptom of major depressive disorder (MDD), the neurobiological mechanisms of which remain poorly understood. Despite decades of speculation regarding the role of dopamine (DA) in anhedonic symptoms, empirical evidence has remained elusive, with frequent reports of contradictory findings. In the present review, we argue that this has resulted from an underspecified definition of anhedonia, which has failed to dissociate between consummatory and motivational aspects of reward behavior. Given substantial preclinical evidence that DA is involved primarily in motivational aspects of reward, we suggest that a refined definition of anhedonia that distinguishes between deficits in pleasure and motivation is essential for the purposes of identifying its neurobiological substrates. Moreover, bridging the gap between preclinical and clinical models of anhedonia may require moving away from the conceptualization of anhedonia as a steady-state, mood-like phenomena. Consequently, we introduce the term "decisional anhedonia" to address the influence of anhedonia on reward decision-making. These proposed modifications to the theoretical definition of anhedonia have implications for research, assessment and treatment of MDD. Copyright © 2010 Elsevier Ltd. All rights reserved.
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            Phantom auditory perception (tinnitus): mechanisms of generation and perception.

            Phantom auditory perception--tinnitus--is a symptom of many pathologies. Although there are a number of theories postulating certain mechanisms of its generation, none have been proven yet. This paper analyses the phenomenon of tinnitus from the point of view of general neurophysiology. Existing theories and their extrapolation are presented, together with some new potential mechanisms of tinnitus generation, encompassing the involvement of calcium and calcium channels in cochlear function, with implications for malfunction and aging of the auditory and vestibular systems. It is hypothesized that most tinnitus results from the perception of abnormal activity, defined as activity which cannot be induced by any combination of external sounds. Moreover, it is hypothesized that signal recognition and classification circuits, working on holographic or neuronal network-like representation, are involved in the perception of tinnitus and are subject to plastic modification. Furthermore, it is proposed that all levels of the nervous system, to varying degrees, are involved in tinnitus manifestation. These concepts are used to unravel the inexplicable, unique features of tinnitus and its masking. Some clinical implications of these theories are suggested.
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              The diagnosis and management of rhinitis: an updated practice parameter.

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                Author and article information

                Contributors
                Journal
                BMC Ear Nose Throat Disord
                BMC Ear Nose Throat Disord
                BMC Ear, Nose, and Throat Disorders
                BioMed Central
                1472-6815
                2013
                23 July 2013
                : 13
                : 8
                Affiliations
                [1 ]Laboratory of Neurogenetics and Behavior, Rockefeller University, New York, NY, USA
                [2 ]Department of Psychiatry, New York University School of Medicine, New York, NY, USA
                [3 ]Creedmoor Psychiatric Center, New York State Office of Mental Health, New York, NY, USA
                Article
                1472-6815-13-8
                10.1186/1472-6815-13-8
                3733708
                23875929
                f3b7671b-2c89-4877-8761-258a69a117d4
                Copyright © 2013 Keller and Malaspina; licensee BioMed Central Ltd.

                This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                : 25 March 2013
                : 15 July 2013
                Categories
                Research Article

                Otolaryngology
                olfaction,quality of life,anosmia,phantosmia,parosmia,anhedonia
                Otolaryngology
                olfaction, quality of life, anosmia, phantosmia, parosmia, anhedonia

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