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      Increased physical activity was associated with less weight regain six years after “The Biggest Loser” competition

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          Abstract

          Objective

          To explore how physical activity (PA) and energy intake (EI) changes were related to weight loss and regain following the Biggest Loser competition.

          Methods

          At baseline, six weeks, 30 weeks, and six years after the competition we measured body composition via dual energy X-ray absorptiometry, resting energy expenditure using indirect calorimetry, and EI and PA using doubly labeled water.

          Results

          Six years after the competition, median weight loss in 14 Biggest Loser participants was 13%, with those maintaining greater weight loss (mean ± SE) of 24.9 ± 3.8% having increased PA by 160 ± 23% compared to a PA increase of 34 ± 25 % (p = 0.0033) in the weight regainers who were 1.1 ± 4.0% heavier than the pre-competition baseline. EI changes were similar between weight loss maintainers and regainers (−8.7 ± 5.6% vs −7.4± 2.7 %, respectively; p=0.83). Weight regain was inversely associated with absolute changes in PA (r= −0.82, p=0.0003) but not with changes in EI (r = −0.15, p=0.61). EI and PA changes explained 93% of the individual weight loss variability at six years.

          Conclusions

          Consistent with previous reports, large persistent increases in physical activity may be required for long-term maintenance of lost weight.

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          Most cited references30

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          Eight-Year Weight Losses with an Intensive Lifestyle Intervention: The Look AHEAD Study

          (2014)
          Objective To evaluate 8-year weight losses achieved with intensive lifestyle intervention (ILI) in the Look AHEAD (Action for Health in Diabetes) study. Design and Methods Look AHEAD assessed the effects of intentional weight loss on cardiovascular morbidity and mortality in 5,145 overweight/obese adults with type 2 diabetes, randomly assigned to ILI or usual care (i.e., diabetes support and education [DSE]). The ILI provided comprehensive behavioral weight loss counseling over 8 years; DSE participants received periodic group education only. Results All participants had the opportunity to complete 8 years of intervention before Look AHEAD was halted in September 2012; ≥88% of both groups completed the 8-year outcomes assessment. ILI and DSE participants lost (mean±SE) 4.7±0.2% and 2.1±0.2% of initial weight, respectively (p<0.001) at year 8; 50.3% and 35.7%, respectively, lost ≥5% (p<0.001), and 26.9% and 17.2%, respectively, lost ≥10% (p<0.001). Across the 8 years ILI participants, compared with DSE, reported greater practice of several key weight-control behaviors. These behaviors also distinguished ILI participants who lost ≥10% and kept it off from those who lost but regained. Conclusions Look AHEAD’s ILI produced clinically meaningful weight loss (≥5%) at year 8 in 50% of patients with type 2 diabetes and can be used to manage other obesity-related co-morbid conditions. Trial Registration clinicaltrials.gov Identifier: NCT00017953
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            Weight-loss maintenance for 10 years in the National Weight Control Registry.

            The challenge of weight-loss maintenance is well known, but few studies have followed successful weight losers over an extended period or evaluated the effect of behavior change on weight trajectories. To study the weight-loss trajectories of successful weight losers in the National Weight Control Registry (NWCR) over a 10-year period, and to evaluate the effect of behavior change on weight-loss trajectories. A 10-year observational study of self-reported weight loss and behavior change in 2886 participants (78% female; mean age 48 years) in the NWCR who at entry had lost at least 30 lbs (13.6 kg) and kept it off for at least one year. Data were collected in 1993-2010; analysis was conducted in 2012. Weight loss (kilograms; percent weight loss from maximum weight). Mean weight loss was 31.3 kg (95% CI=30.8, 31.9) at baseline, 23.8 kg (95% CI=23.2, 24.4) at 5 years and 23.1±0.4 kg (95% CI=22.3, 23.9) at 10 years. More than 87% of participants were estimated to be still maintaining at least a 10% weight loss at Years 5 and 10. Larger initial weight losses and longer duration of maintenance were associated with better long-term outcomes. Decreases in leisure-time physical activity, dietary restraint, and frequency of self-weighing and increases in percentage of energy intake from fat and disinhibition were associated with greater weight regain. The majority of weight lost by NWCR members is maintained over 10 years. Long-term weight-loss maintenance is possible and requires sustained behavior change. © 2013 American Journal of Preventive Medicine Published by American Journal of Preventive Medicine All rights reserved.
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              Calorie for Calorie, Dietary Fat Restriction Results in More Body Fat Loss than Carbohydrate Restriction in People with Obesity.

              Dietary carbohydrate restriction has been purported to cause endocrine adaptations that promote body fat loss more than dietary fat restriction. We selectively restricted dietary carbohydrate versus fat for 6 days following a 5-day baseline diet in 19 adults with obesity confined to a metabolic ward where they exercised daily. Subjects received both isocaloric diets in random order during each of two inpatient stays. Body fat loss was calculated as the difference between daily fat intake and net fat oxidation measured while residing in a metabolic chamber. Whereas carbohydrate restriction led to sustained increases in fat oxidation and loss of 53 ± 6 g/day of body fat, fat oxidation was unchanged by fat restriction, leading to 89 ± 6 g/day of fat loss, and was significantly greater than carbohydrate restriction (p = 0.002). Mathematical model simulations agreed with these data, but predicted that the body acts to minimize body fat differences with prolonged isocaloric diets varying in carbohydrate and fat.
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                Author and article information

                Journal
                101264860
                32902
                Obesity (Silver Spring)
                Obesity (Silver Spring)
                Obesity (Silver Spring, Md.)
                1930-7381
                1930-739X
                23 August 2017
                November 2017
                01 November 2018
                : 25
                : 11
                : 1838-1843
                Affiliations
                [1 ]National Institute of Diabetes and Digestive and Kidney Diseases
                [2 ]Washington DC Veterans Affairs Medical Center
                [3 ]Towson University
                Author notes
                [* ]To whom correspondence should be addressed: Kevin D. Hall, PhD, National Institute of Diabetes & Digestive & Kidney Diseases, National Institutes of Health, 12A South Drive, Room 4007, Bethesda, MD 20892-5621, phone: 301-402-8248, fax: 301-402-0535, kevinh@ 123456niddk.nih.gov
                Article
                NIHMS899202
                10.1002/oby.21986
                5757520
                29086499
                f2d40542-332a-47eb-82fd-45b66b1b92c4

                Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms

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                Medicine

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