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      Effectiveness of a skin care programme for the prevention of contact dermatitis in healthcare workers (the Healthy Hands Project): A single‐centre, cluster randomized controlled trial

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          Abstract

          Background

          Healthcare workers (HCWs) are at risk of developing hand dermatitis (HD). Guidelines recommend moisturizers to prevent HD, but in practice their effectiveness has been poorly investigated.

          Objectives

          To assess whether an intervention aimed at improving skin care leads to a reduction in HD severity.

          Methods

          In this 1‐year randomized controlled trial, 9 wards (285 HCWs) were allocated to an intervention group (IG), and 10 wards (216 HCWs) were allocated to the control group (CG). The intervention included provision of cream dispensers with electronic monitoring of use, regularly communicated to the HCWs. The primary and secondary outcomes were change from baseline in Hand Eczema Severity Index (HECSI) score (ΔHECSI) and change in natural moisturizing factor (NMF) level (ΔNMF).

          Results

          At 12 months, the rates of loss to follow‐up were 41% and 39% in the IG and the CG, respectively. The HECSI score was reduced in the IG by −6.2 points (95%CI: −7.7 to −4.7) and in the CG by −4.2 points (95%CI: −6.0 to −2.4). There was no significant difference in ΔHECSI or ΔNMF between the groups. Relative improvement in the HECSI score was significantly higher in the IG than in the CG (56% vs 44%). In a subgroup of HCWs with mild HD, the IG showed a larger HECSI score decrease than the CG ( P < 0.001).

          Conclusion

          Although there was no significant effect on the primary outcomes, the intervention showed overall positive effects on the HECSI score.

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          Most cited references33

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          Moisturization and skin barrier function.

          Over the past decade, great progress has been made toward elucidating the structure and function of the stratum corneum (SC), the outermost layer of the epidermis. SC cells (corneocytes) protect against desiccation and environmental challenge by regulating water flux and retention. Maintenance of an optimal level of hydration by the SC is largely dependent on several factors. First, intercellular lamellar lipids, organized predominantly in an orthorhombic gel phase, provide an effective barrier to the passage of water through the tissue. Secondly, the diffusion path length also retards water loss, since water must traverse the tortuous path created by the SC layers and corneocyte envelopes. Thirdly, and equally important, is natural moisturizing factor (NMF), a complex mixture of low-molecular-weight, water-soluble compounds first formed within the corneocytes by degradation of the histidine-rich protein known as filaggrin. Each maturation step leading to the formation of an effective moisture barrier--including corneocyte strengthening, lipid processing, and NMF generation--is influenced by the level of SC hydration. These processes, as well as the final step of corneodesmolysis that mediates exfoliation, are often disturbed upon environmental challenge, resulting in dry, flaky skin conditions. The present paper reviews our current understanding of the biology of the SC, particularly its homeostatic mechanisms of hydration.
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            The hand eczema severity index (HECSI): a scoring system for clinical assessment of hand eczema. A study of inter- and intraobserver reliability.

            There is a need for a standardized clinical grading system for a more objective and accurate assessment of the severity of hand eczema (HE). To develop and validate a scoring system called the hand eczema severity index (HECSI) designed for clinical assessment of HE. Twelve dermatologists (observers) assessed 15 HE patients twice, with an interval of 30 min. The study was performed blinded for the observers, and only the hands and wrists of the patients were visible to the observers. Agreement between the observers was determined by using the intraclass correlation coefficient (ICC), which is the correlation between (single) ratings of the same patient. ICC for total HECSI score was 0.79 at the first assessment and 0.84 at the second assessment. ICC for intraobserver agreement was 0.90. Overall excellent agreement existed for both inter- and intraobserver reliability and the scoring system is suggested for use in future clinical studies on HE. Because HECSI is an entirely objective assessment of clinical signs, in addition, inclusion of patient-rated symptoms should be considered.
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              Increasing ICU staff handwashing: effects of education and group feedback.

              This study provides an evaluation of the effectiveness of methods to increase handwashing (HW) by nurses working in an intensive care unit. After baseline observations, two interventions were implemented in sequence: three series of classes conducted by the infection control nurse (ICN); and feedback to staff about handwashing errors on the previous day. Staff were aware that handwashing was being observed throughout the study. The educational intervention produced an immediate increase in HW that was followed by a decline to baseline rates over four weeks. Feedback produced an improvement to 97% compliance that was sustained until completion of the study. Improvement in HW compliance following specified critical procedures was also observed following interventions.
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                Author and article information

                Contributors
                s.kezic@amc.uva.nl
                Journal
                Contact Dermatitis
                Contact Derm
                10.1111/(ISSN)1600-0536
                COD
                Contact Dermatitis
                Blackwell Publishing Ltd (Oxford, UK )
                0105-1873
                1600-0536
                15 March 2019
                June 2019
                : 80
                : 6 ( doiID: 10.1111/cod.2019.80.issue-6 )
                : 365-373
                Affiliations
                [ 1 ] Coronel Institute of Occupational Health, Amsterdam Public Health Research Institute Amsterdam The Netherlands
                [ 2 ] Department of Dermatology Amsterdam UMC (De Boelelaan) Amsterdam The Netherlands
                [ 3 ] Department of Dermatology Amsterdam UMC (Meibergdreef) Amsterdam The Netherlands
                Author notes
                [*] [* ] Correspondence

                Dr Sanja Kezic.

                Email: s.kezic@ 123456amc.uva.nl

                Author information
                https://orcid.org/0000-0002-1408-4351
                https://orcid.org/0000-0002-1063-4547
                https://orcid.org/0000-0001-7580-0684
                Article
                COD13214
                10.1111/cod.13214
                6593800
                30652317
                f0f6c914-7e87-4393-acfc-42920e2c3e83
                © 2019 The Authors. Contact Dermatitis published by John Wiley & Sons Ltd.

                This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

                History
                : 28 August 2018
                : 02 December 2018
                : 10 December 2018
                Page count
                Figures: 1, Tables: 3, Pages: 9, Words: 7491
                Funding
                Funded by: DEB Group Ltd, Denby, UK
                Categories
                Original Article
                Original Articles
                Custom metadata
                2.0
                cod13214
                June 2019
                Converter:WILEY_ML3GV2_TO_NLMPMC version:5.6.5 mode:remove_FC converted:26.06.2019

                hand dermatitis,hand moisturizers,healthcare,nurses,prevention

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