1
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      The Vestigial and Scalloped proteins act together to directly regulate wing-specific gene expression in Drosophila.

      Genes & development
      Animals, Base Sequence, Binding Sites, Body Patterning, genetics, Cell Line, Cell Nucleus, metabolism, DNA Footprinting, DNA-Binding Proteins, isolation & purification, Drosophila Proteins, Drosophila melanogaster, embryology, Enhancer Elements, Genetic, Gene Expression Regulation, Developmental, Genes, Insect, Models, Biological, Molecular Sequence Data, Nuclear Proteins, Recombinant Fusion Proteins, Sequence Deletion, Signal Transduction, Transcription Factors, Wing

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          A small number of major regulatory (selector) genes have been identified in animals that control the development of particular organs or complex structures. In Drosophila, the vestigial gene is required for wing formation and is able to induce wing-like outgrowths on other structures. However, the molecular function of the nuclear Vestigial protein, which bears no informative similarities to other proteins, was unknown. Here, we show that Vestigial requires the function of the Scalloped protein, a member of the TEA family of transcriptional regulators, to directly activate the expression of genes involved in wing morphogenesis. Genetic and molecular analyses reveal that Vestigial regulates wing identity by forming a complex with the Scalloped protein that binds sequence specifically to essential sites in wing-specific enhancers. These enhancers also require the direct inputs of signaling pathways, and the response of an enhancer can be switched to another pathway through changes in signal-transducer binding sites. Combinatorial regulation by selector proteins and signal transducers is likely to be a general feature of the tissue-specific control of gene expression during organogenesis.

          Related collections

          Author and article information

          Comments

          Comment on this article

          scite_
          218
          9
          253
          1
          Smart Citations
          218
          9
          253
          1
          Citing PublicationsSupportingMentioningContrasting
          View Citations

          See how this article has been cited at scite.ai

          scite shows how a scientific paper has been cited by providing the context of the citation, a classification describing whether it supports, mentions, or contrasts the cited claim, and a label indicating in which section the citation was made.

          Similar content559

          Cited by54