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Angiotensin-converting enzyme inhibitor rapidly ameliorates depressive-type behaviors via bradykinin-dependent activation of mTORC1
Han Luo ,
Peng-Fei Wu ,
Yu Cao ,
Ming Jin ,
Tian-Tian Shen ,
Ji Wang ,
Jian-Geng Huang ,
Qian-Qian Han ,
Jin-Gang He ,
Si-Long Deng ,
Lan Ni ,
Zhuang-Li Hu ,
Li-Hong Long ,
Fang Wang ,
Jian-Guo Chen
February 2020
February 2020
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Abstract
Angiotensin-converting enzyme inhibitors (ACEIs) are widely prescribed antihypertensive
agents. Intriguingly, case reports and clinical trials have indicated that ACEIs,
including captopril and lisinopril, may have a rapid mood-elevating effect in certain
patients, but few experimental studies have investigated their value as fast-onset
antidepressants.
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