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      Health equity, care access and quality in headache – part 2

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          Abstract

          Background

          Headache disorders are a global public health concern affecting diverse populations. This review examines headache service organizations in low-, middle-, and high-income countries. It addresses global challenges in pharmacological headache treatment, with a focus on safety, tolerability, reproductive and child health, and outlines disparities in accessing innovative treatments worldwide.

          Main body

          Organized headache services are essential due to the wide prevalence and varying severity of headache disorders. The tiered headache service model is globally recognized, although its implementation varies based on financial and workforce considerations. Headache burden affects well-being, causing disability, economic challenges, and work limitations, irrespective of location or income. All nations still require improved diagnosis and treatment, and the majority of countries face obstacles including limited access, awareness, economic barriers, and inadequate health policies. Provided adequate internet availability, telemedicine could help improve health equity by expanding access to headache care, since it can offer patients access to services without lengthy waiting times or extensive travel and can provide healthcare unavailable in underserved areas due to staff shortages.

          Numerous health disparities restrict global access to many headache medications, especially impacting individuals historically excluded from randomized controlled trials, such as those with cardiovascular and cerebrovascular conditions, as well as pregnant women. Furthermore, despite advancements in researching migraine treatments for young patients, the options for treatment remain limited.

          Access to headache treatment relies on factors like medication availability, approval, financial coverage, and healthcare provider expertise. Inadequate public awareness leads to neglect by policymakers and undertreatment by patients and healthcare providers. Global access discrepancies are exacerbated by the introduction of novel disease-specific medications, particularly impacting Asian, African, and Latin American nations excluded from clinical trials. While North America and Europe experience broad availability of migraine treatments, the majority of countries worldwide lack access to these therapies.

          Conclusions

          Healthcare disparities, treatment access, and medication availability are concerning issues in headache medicine. Variations in national healthcare systems impact headache management, and costly innovative drugs are widening these gaps. Healthcare practitioners and experts should acknowledge these challenges and work towards minimizing access barriers for equitable global headache care in the future.

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          Most cited references129

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          The global burden of headache: a documentation of headache prevalence and disability worldwide.

          This study, which is a part of the initiative 'Lifting The Burden: The Global Campaign to Reduce the Burden of Headache Worldwide', assesses and presents all existing evidence of the world prevalence and burden of headache disorders. Population-based studies applying International Headache Society criteria for migraine and tension-type headache, and also studies on headache in general and 'chronic daily headache', have been included. Globally, the percentages of the adult population with an active headache disorder are 46% for headache in general, 11% for migraine, 42% for tension-type headache and 3% for chronic daily headache. Our calculations indicate that the disability attributable to tension-type headache is larger worldwide than that due to migraine. On the World Health Organization's ranking of causes of disability, this would bring headache disorders into the 10 most disabling conditions for the two genders, and into the five most disabling for women.
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            Migraine: epidemiology and systems of care

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              Sex differences in the epidemiology, clinical features, and pathophysiology of migraine.

              Migraine is two to three times more prevalent in women than men, and women report a longer attack duration, increased risk of headache recurrence, greater disability, and a longer period of time required to recover. Conditions recognised to be comorbid with migraine include asthma, anxiety, depression, and other chronic pain conditions, and these comorbidities add to the amount of disability in both sexes. Migraine-specifically migraine with aura-has been identified as a risk factor for vascular disorders, particularly in women, but because of the scarcity of data, the comparative risk in men has yet to be established. There is evidence implicating the role of female sex hormones as a major factor in determining migraine risk and characteristics, which accounts for sex differences, but there is also evidence to support underlying genetic variance. Although migraine is often recognised in women, it is underdiagnosed in men, resulting in suboptimal management and less participation of men in clinical trials.
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                Author and article information

                Contributors
                bianca.raffaelli@charite.de
                Journal
                J Headache Pain
                J Headache Pain
                The Journal of Headache and Pain
                Springer Milan (Milan )
                1129-2369
                1129-2377
                13 December 2023
                13 December 2023
                2023
                : 24
                : 1
                : 167
                Affiliations
                [1 ]GRID grid.6363.0, ISNI 0000 0001 2218 4662, Department of Neurology, , Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität Zu Berlin, ; Charitéplatz 1, 10117 Berlin, Germany
                [2 ]GRID grid.484013.a, ISNI 0000 0004 6879 971X, Clinician Scientist Program, , Berlin Institute of Health (BIH), ; Berlin, Germany
                [3 ]Headache Group, Wolfson SPaRC, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, ( https://ror.org/0220mzb33) London, UK
                [4 ]Department of Neurology, Dongtan Sacred Heart Hospital, Hallym University College of Medicine, ( https://ror.org/03sbhge02) Hwaseong, Korea
                [5 ]Department of Brain and Behavioral Sciences, University of Pavia, ( https://ror.org/00s6t1f81) Pavia, Italy
                [6 ]GRID grid.419416.f, ISNI 0000 0004 1760 3107, Headache Science & Neurorehabilitation Unit, , IRCCS Mondino Foundation, ; Pavia, Italy
                [7 ]Department of Physical Therapy and Rehabilitation, Faculty of Health Sciences, Yozgat Bozok University, ( https://ror.org/04qvdf239) Yozgat, Türkiye
                [8 ]Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila, ( https://ror.org/01j9p1r26) L’Aquila, Italy
                [9 ]GRID grid.5252.0, ISNI 0000 0004 1936 973X, Department of Neurology, , LMU University Hospital, LMU Munich, ; Munich, Germany
                [10 ]German Migraine and Headache Society, Frankfurt, Germany
                [11 ]Department of Neurology, Wroclaw Medical University, ( https://ror.org/01qpw1b93) Wroclaw, Poland
                [12 ]GRID grid.18887.3e, ISNI 0000000417581884, Neuroimaging Research Unit and Neurology Unit, , IRCCS San Raffaele Scientific Institute, ; Milan, Italy
                Article
                1699
                10.1186/s10194-023-01699-7
                10717448
                38087219
                eb840e8a-d0c6-4bd2-a9a8-7ed81f045e0f
                © The Author(s) 2023

                Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

                History
                : 28 October 2023
                : 30 November 2023
                Categories
                Review
                Custom metadata
                © Springer-Verlag Italia S.r.l., part of Springer Nature 2023

                Anesthesiology & Pain management
                health inequity,worldwide health,anti-cgrp drugs,migraine,cluster headache,medication overuse

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