Amyloid in dementia associated with familial FTLD: Not an innocent bystander

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

Patients with frontotemporal lobar degeneration (FTLD) can show superimposed amyloid pathology, though the impact of amyloid on the clinical presentation of FTLD is not well characterized. This cross-sectional case-control study compared clinical features, FDG-PET metabolism and gray matter volume loss in 30 patients with familial FTLD in whom amyloid status was confirmed with autopsy or PiB-PET. Compared to the amyloid negative patients, the amyloid positive patients performed significantly worse on several cognitive tests and showed hypometabolism and volume loss in more temporoparietal regions. Our results suggest that in FTLD, amyloid positivity is associated with a more AD-like pattern of neurodegeneration.

Related collections

Author and article information

Journal

Journal ID (nlm-journal-id): 9511374

Journal ID (pubmed-jr-id): 22073

Journal ID (nlm-ta): Neurocase

Journal ID (iso-abbrev): Neurocase

Title: Neurocase

ISSN (Print): 1355-4794

ISSN (Electronic): 1465-3656

Publication date Nihms-submitted: 16 September 2015

Publication date (Electronic): 04 June 2015

Publication date (Print): February 2016

Publication date PMC-release: 01 February 2017

Volume: 22

Issue: 1

Pages: 76-83

Affiliations

[1 ]Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA

[2 ]Department of Radiology, University of California, San Francisco, San Francisco, CA, USA

[3 ]School of public health, University of California Berkeley, and Lawrence Berkeley national labs, Berkeley, CA, USA

[4 ]Department of Psychiatry, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, Los Angeled, CA, USA

Author notes

[* ] Corresponding Author: Georges Naasan, MD, Assistant Professor of Neurology, University of California, San Francisco, Memory and Aging Center, 1500 Owens Street, Suite 320, San Francisco, CA 94158, Phone: 415-502-0551, gnaasan@ 123456memory.ucsf.edu

Article

Accession ID: PMC4662906 Pmcid ID: PMC4662906 Pmc-uid ID: 4662906 Manuscript ID: nihpa698858

DOI: 10.1080/13554794.2015.1046458

PMC ID: 4662906

PubMed ID: 26040468

SO-VID: e983a94c-2f9f-4360-9c21-744cc351b014

History

Comments

Comment on this article

scite_

Cited by 7

See all cited by

- Version 1